Effect of long acting somatostatin-analogue, SMS 201995, on gut hormone secretion in normal subjects

M. E. Kraenzlin; S. M. Wood; M. Neufeld; T. E. Adrian; S. R. Bloom

doi:10.1007/BF02012573

Effect of long acting somatostatin-analogue, SMS 201995, on gut hormone secretion in normal subjects

M. E. Kraenzlin, S. M. Wood, M. Neufeld, T. E. Adrian, S. R. Bloom

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

SMS 201 995 is a new long acting analogue of somatostatin. We have investigated its effect on basal and meal stimulated secretion of gut hormones and have shown that after a single s. c. injection of 50 μg it lowers significantly the basal plasma levels of pancreatic polypeptide, secretin, motilin, pancreatic glucagon and insulin, it also effectively suppresses the postprandial release of pancreatic polypeptide, gastrin, secretin, gastric inhibitory peptide, pancreatic glucagon and insulin. Except for the usual brief discomfort of an injection, no symptoms or untoward effects were observed.

Original language	English
Pages (from-to)	738-740
Number of pages	3
Journal	Experientia
Volume	41
Issue number	6
DOIs	https://doi.org/10.1007/BF02012573
Publication status	Published - Jun 1985
Externally published	Yes

Keywords

Somatostatin analogue
gut hormones

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/BF02012573

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abstract = "SMS 201 995 is a new long acting analogue of somatostatin. We have investigated its effect on basal and meal stimulated secretion of gut hormones and have shown that after a single s. c. injection of 50 μg it lowers significantly the basal plasma levels of pancreatic polypeptide, secretin, motilin, pancreatic glucagon and insulin, it also effectively suppresses the postprandial release of pancreatic polypeptide, gastrin, secretin, gastric inhibitory peptide, pancreatic glucagon and insulin. Except for the usual brief discomfort of an injection, no symptoms or untoward effects were observed.",

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AU - Kraenzlin, M. E.

AU - Wood, S. M.

AU - Neufeld, M.

AU - Adrian, T. E.

AU - Bloom, S. R.

PY - 1985/6

Y1 - 1985/6

N2 - SMS 201 995 is a new long acting analogue of somatostatin. We have investigated its effect on basal and meal stimulated secretion of gut hormones and have shown that after a single s. c. injection of 50 μg it lowers significantly the basal plasma levels of pancreatic polypeptide, secretin, motilin, pancreatic glucagon and insulin, it also effectively suppresses the postprandial release of pancreatic polypeptide, gastrin, secretin, gastric inhibitory peptide, pancreatic glucagon and insulin. Except for the usual brief discomfort of an injection, no symptoms or untoward effects were observed.

AB - SMS 201 995 is a new long acting analogue of somatostatin. We have investigated its effect on basal and meal stimulated secretion of gut hormones and have shown that after a single s. c. injection of 50 μg it lowers significantly the basal plasma levels of pancreatic polypeptide, secretin, motilin, pancreatic glucagon and insulin, it also effectively suppresses the postprandial release of pancreatic polypeptide, gastrin, secretin, gastric inhibitory peptide, pancreatic glucagon and insulin. Except for the usual brief discomfort of an injection, no symptoms or untoward effects were observed.

KW - Somatostatin analogue

KW - gut hormones

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ER -

Effect of long acting somatostatin-analogue, SMS 201995, on gut hormone secretion in normal subjects

Abstract

Keywords

ASJC Scopus subject areas

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