Effect of long acting somatostatin-analogue, SMS 201995, on gut hormone secretion in normal subjects

M. E. Kraenzlin, S. M. Wood, M. Neufeld, T. E. Adrian, S. R. Bloom

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

SMS 201 995 is a new long acting analogue of somatostatin. We have investigated its effect on basal and meal stimulated secretion of gut hormones and have shown that after a single s. c. injection of 50 μg it lowers significantly the basal plasma levels of pancreatic polypeptide, secretin, motilin, pancreatic glucagon and insulin, it also effectively suppresses the postprandial release of pancreatic polypeptide, gastrin, secretin, gastric inhibitory peptide, pancreatic glucagon and insulin. Except for the usual brief discomfort of an injection, no symptoms or untoward effects were observed.

Original languageEnglish
Pages (from-to)738-740
Number of pages3
JournalExperientia
Volume41
Issue number6
DOIs
Publication statusPublished - Jun 1985
Externally publishedYes

Keywords

  • Somatostatin analogue
  • gut hormones

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology

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