Effect of naloxone on the antral motor response to solid food in man

G. R. SHARPE, W. D.W. REES, T. E. ADRIAN, N. D. CHRISTOFIDES, S. R. BLOOM

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Abstract. Antroduodenal motor activity was recorded in eight healthy subjects using perfused tubes connected to external strain gauge transducers. Each subject was studied over a 2·5‐h period following ingestion of a solid meal, on 2 separate days. Intravenous saline was administered on one day and saline plus naloxone (40 μg kg−1 h−1) on the other, in randomized order. Naloxone markedly inhibited the antral motor response to food and this effect was due to decreased amplitude and contractile frequency. The duodenal motor response to solid food and the postprandial rise in serum gastrin and plasma pancreatic polypeptide were not altered by naloxone. These observations suggest that peripheral or central opiate receptors play a role in regulating the antral motor response to food. 1987 European Society for Clinical Investigation

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalEuropean Journal of Clinical Investigation
Volume17
Issue number2
DOIs
Publication statusPublished - Apr 1987
Externally publishedYes

Keywords

  • Gastric motility
  • naloxone

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

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