Abstract
Abstract. Antroduodenal motor activity was recorded in eight healthy subjects using perfused tubes connected to external strain gauge transducers. Each subject was studied over a 2·5‐h period following ingestion of a solid meal, on 2 separate days. Intravenous saline was administered on one day and saline plus naloxone (40 μg kg−1 h−1) on the other, in randomized order. Naloxone markedly inhibited the antral motor response to food and this effect was due to decreased amplitude and contractile frequency. The duodenal motor response to solid food and the postprandial rise in serum gastrin and plasma pancreatic polypeptide were not altered by naloxone. These observations suggest that peripheral or central opiate receptors play a role in regulating the antral motor response to food. 1987 European Society for Clinical Investigation
Original language | English |
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Pages (from-to) | 95-99 |
Number of pages | 5 |
Journal | European Journal of Clinical Investigation |
Volume | 17 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 1987 |
Externally published | Yes |
Keywords
- Gastric motility
- naloxone
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry