Effect of neurotensin on pancreatic function in man

DR Fletcher, AM Blackburn, TE Adrian, VS Chadwick, SR Bloom

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)


The effect of neurotensin on submaximally-stimulated hepatobiliary and pancreatic secretion was studied in 6 healthy subjects. An intravenous infusion of neurotensin 1.4 ± 0.3 pmol/kg/min, designed to reproduce plasma neurotensin immunoreactivity levels within the physiological range, produced a significant increase in pancreatic bicarbonate output. Plasma concentrations of pancreatic polypeptide rose by 83 ± 16 pmol/l and were associated with a small reduction in trypsin, but no significant change in bilirubin outputs.

Original languageEnglish
Pages (from-to)2157-2161
Number of pages5
JournalLife Sciences
Issue number21
Publication statusPublished - Nov 23 1981
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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