Effect of neurotensin on pancreatic function in man

DR Fletcher; AM Blackburn; TE Adrian; VS Chadwick; SR Bloom

doi:10.1016/0024-3205(81)90485-9

Effect of neurotensin on pancreatic function in man

DR Fletcher
, AM Blackburn
, TE Adrian
, VS Chadwick
, SR Bloom

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

The effect of neurotensin on submaximally-stimulated hepatobiliary and pancreatic secretion was studied in 6 healthy subjects. An intravenous infusion of neurotensin 1.4 ± 0.3 pmol/kg/min, designed to reproduce plasma neurotensin immunoreactivity levels within the physiological range, produced a significant increase in pancreatic bicarbonate output. Plasma concentrations of pancreatic polypeptide rose by 83 ± 16 pmol/l and were associated with a small reduction in trypsin, but no significant change in bilirubin outputs.

Original language	English
Pages (from-to)	2157-2161
Number of pages	5
Journal	Life Sciences
Volume	29
Issue number	21
DOIs	https://doi.org/10.1016/0024-3205(81)90485-9
Publication status	Published - Nov 23 1981
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry,Genetics and Molecular Biology

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10.1016/0024-3205(81)90485-9

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title = "Effect of neurotensin on pancreatic function in man",

abstract = "The effect of neurotensin on submaximally-stimulated hepatobiliary and pancreatic secretion was studied in 6 healthy subjects. An intravenous infusion of neurotensin 1.4 ± 0.3 pmol/kg/min, designed to reproduce plasma neurotensin immunoreactivity levels within the physiological range, produced a significant increase in pancreatic bicarbonate output. Plasma concentrations of pancreatic polypeptide rose by 83 ± 16 pmol/l and were associated with a small reduction in trypsin, but no significant change in bilirubin outputs.",

author = "DR Fletcher and AM Blackburn and TE Adrian and VS Chadwick and SR Bloom",

note = "Funding Information: Ann M Blackburn is a recipient of a Research Fellowship from the Medical Research Council. We thank James Barr and Linda Fletcher for skilled technical assistance.",

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AU - Fletcher, DR

AU - Blackburn, AM

AU - Adrian, TE

AU - Chadwick, VS

AU - Bloom, SR

N1 - Funding Information: Ann M Blackburn is a recipient of a Research Fellowship from the Medical Research Council. We thank James Barr and Linda Fletcher for skilled technical assistance.

PY - 1981/11/23

Y1 - 1981/11/23

N2 - The effect of neurotensin on submaximally-stimulated hepatobiliary and pancreatic secretion was studied in 6 healthy subjects. An intravenous infusion of neurotensin 1.4 ± 0.3 pmol/kg/min, designed to reproduce plasma neurotensin immunoreactivity levels within the physiological range, produced a significant increase in pancreatic bicarbonate output. Plasma concentrations of pancreatic polypeptide rose by 83 ± 16 pmol/l and were associated with a small reduction in trypsin, but no significant change in bilirubin outputs.

AB - The effect of neurotensin on submaximally-stimulated hepatobiliary and pancreatic secretion was studied in 6 healthy subjects. An intravenous infusion of neurotensin 1.4 ± 0.3 pmol/kg/min, designed to reproduce plasma neurotensin immunoreactivity levels within the physiological range, produced a significant increase in pancreatic bicarbonate output. Plasma concentrations of pancreatic polypeptide rose by 83 ± 16 pmol/l and were associated with a small reduction in trypsin, but no significant change in bilirubin outputs.

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UR - https://www.scopus.com/pages/publications/0019771647#tab=citedBy

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DO - 10.1016/0024-3205(81)90485-9

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VL - 29

SP - 2157

EP - 2161

JO - Life Sciences

JF - Life Sciences

IS - 21

ER -

Effect of neurotensin on pancreatic function in man

Abstract

ASJC Scopus subject areas

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