Effect of organic solvents on the inclusion of sparfloxacin and norfloxacin with β-cyclodextrin

Nathir A.F. Al-Rawashdeh

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The complexation of sparfloxacin (SPR) and norfloxacin (NOR) by β-cyclodextrin (β-CD) in water and in mixed organic/aqueous media has been studied by absorption spectroscopy. Three organic solvents [dimethyl-sulphoxide, ethanol and 2-methyl-1-propanol have been adopted which differ in polarity and hydrophobicity. It has been shown that the presence of organic solvent causes the degradation of the 1: 1 SPR: β-CD and NOR: β-CD complexes. The binding constants of the inclusion complexes of SPR and NOR with β-CD in water are greater than those with mixed organic-water media. The higher the hydrophobicity of the co-solvent the weaker the complexation of SPR and NOR by β-CD.

Original languageEnglish
Pages (from-to)483-488
Number of pages6
JournalAsian Journal of Chemistry
Volume16
Issue number1
Publication statusPublished - Jan 1 2004

Keywords

  • 2-Methyl-1-propanol
  • Norfloxacin
  • Sparfloxacin
  • β-Cyclodextrin

ASJC Scopus subject areas

  • General Chemistry

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