Abstract
The complexation of sparfloxacin (SPR) and norfloxacin (NOR) by β-cyclodextrin (β-CD) in water and in mixed organic/aqueous media has been studied by absorption spectroscopy. Three organic solvents [dimethyl-sulphoxide, ethanol and 2-methyl-1-propanol have been adopted which differ in polarity and hydrophobicity. It has been shown that the presence of organic solvent causes the degradation of the 1: 1 SPR: β-CD and NOR: β-CD complexes. The binding constants of the inclusion complexes of SPR and NOR with β-CD in water are greater than those with mixed organic-water media. The higher the hydrophobicity of the co-solvent the weaker the complexation of SPR and NOR by β-CD.
| Original language | English |
|---|---|
| Pages (from-to) | 483-488 |
| Number of pages | 6 |
| Journal | Asian Journal of Chemistry |
| Volume | 16 |
| Issue number | 1 |
| Publication status | Published - Jan 1 2004 |
Keywords
- 2-Methyl-1-propanol
- Norfloxacin
- Sparfloxacin
- β-Cyclodextrin
ASJC Scopus subject areas
- Chemistry(all)