Abstract
The present study was designed to investigate the effect of pioglitazone on muscle strength, a major component of physical performance as assessed by grip strength test in streptozotocin-induced diabetic mice. Pioglitazone is a peroxisome proliferator activated receptor agonist acts as an insulin sensitizer. Swiss albino mice of either sex were intraperitoneally administered multiple low dose of streptozotocin for five days to produce diabetes mellitus. Three weeks after diabetes mellitus establishment in mice, pioglitazone 20 mg/kg was administered orally for four consecutive days. Grip strength test was assessed at baseline, after diabetes induction and after pioglitazone treatment. Pioglitazone treatment improved the muscle strength in diabetic mice as evidenced by a distinct increase in grip strength and enhancement in locomotor activity. The suggested mechanism for pioglitazone treatment associated improvement in grip strength is probably due to increase in insulin sensitivity at skeletal muscles thereby correction of blood glucose levels.
| Original language | English |
|---|---|
| Pages (from-to) | 757-760 |
| Number of pages | 4 |
| Journal | Indian Drugs |
| Volume | 44 |
| Issue number | 10 |
| Publication status | Published - Oct 2007 |
| Externally published | Yes |
Keywords
- Diabetes
- Grip strength test
- Pioglitazone
- Streptozotocin
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
