Effect of statins on abdominal aortic aneurysm

Azar Hosseini, Toktam Sahranavard, Željko Reiner, Tannaz Jamialahmadi, Yusra Al Dhaheri, Ali H. Eid, Amirhossein Sahebkar

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Abdominal aortic aneurysm (AAA) is a prevalent condition which causes progressive growth and rupture of aortic wall with a high death rate. Several studies have found that treatment with statins may decrease the progress of AAA and the risk of rupture by suppressing the inflammatory mediators, decreasing oxidative stress, and inhibiting mechanisms involved in extracellular matrix (ECM) degradation. Moreover, some studies have reported that prehospital therapy with statins can decrease mortality after surgery. The novelty of this paper is that different studies including those performed in humans and animals were reviewed and the potential mechanisms by which statins can have an effect on AAA were summarized. Overall, the evidence suggested an association between treatment with statins and improvement of AAA.

Original languageEnglish
Article number106284
JournalEuropean Journal of Pharmaceutical Sciences
Volume178
DOIs
Publication statusPublished - Nov 1 2022

Keywords

  • Abdominal aortic aneurysm
  • Extracellular matrix
  • Inflammation
  • Oxidative stress
  • Statins

ASJC Scopus subject areas

  • Pharmaceutical Science

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