Effectiveness of BBIBP-CorV vaccine against severe outcomes of COVID-19 in Abu Dhabi, United Arab Emirates

Nawal Al Kaabi, Abderrahim Oulhaj, Subhashini Ganesan, Farida Ismail Al Hosani, Omer Najim, Halah Ibrahim, Juan Acuna, Ahmed R. Alsuwaidi, Ashraf M. Kamour, Ashraf Alzaabi, Badreyya Ahmed Al Shehhi, Habiba Al Safar, Salah Eldin Hussein, Jehad Saleh Abdalla, Dalal Saeed Naser Al Mansoori, Ahmed Abdul Kareem Al Hammadi, Mohammed A. Amari, Ahmed Khamis Al Romaithi, Stefan Weber, Santosh ElavalliIslam Eltantawy, Noura Khamis Alghaithi, Jumana Nafiz Al Azazi, Stephen Geoffrey Holt, Mohamed Mostafa, Rabih Halwani, Hanif Khalak, Wael Elamin, Rami Beiram, Walid Zaher

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

The effectiveness of the inactivated BBIBP-CorV vaccine against severe COVID-19 outcomes (hospitalization, critical care admission and death due to COVID-19) and its long-term effectiveness have not been well characterized among the general population. We conducted a retrospective cohort study using electronic health records of 3,147,869 adults, of which 1,099,886 vaccinated individuals were matched, in a 1:1 ratio to 1,099,886 unvaccinated persons. A Cox-proportional hazard model with time varying coefficients was used to assess the vaccine effectiveness adjusting for age, sex, comorbidity, ethnicity, and the calendar month of entry into the study. Our analysis showed that the effectiveness was 79.6% (95% CI, 77.7 to 81.3) against hospitalization, 86% (95% CI, 82.2 to 89.0) against critical care admission, and 84.1% (95% CI, 70.8 to 91.3) against death due to COVID-19. The effectiveness against these severe outcomes declined over time indicating the need for booster doses to increase protection against severe COVID-19 outcomes.

Original languageEnglish
Article number3215
JournalNature Communications
Volume13
Issue number1
DOIs
Publication statusPublished - Dec 2022

ASJC Scopus subject areas

  • General Chemistry
  • General Biochemistry,Genetics and Molecular Biology
  • General Physics and Astronomy

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