TY - JOUR
T1 - Effects of cognitive remediation therapies on psychotic symptoms and cognitive complaints in patients with schizophrenia and related disorders
T2 - A randomized study
AU - Lecardeur, Laurent
AU - Stip, Emmanuel
AU - Giguere, Michel
AU - Blouin, Guy
AU - Rodriguez, Jean Pierre
AU - Champagne-Lavau, Maud
PY - 2009/6
Y1 - 2009/6
N2 - Background: Cognitive remediation therapy (CRT) has proven to be effective in treating cognitive deficits in schizophrenia. The current study aimed to assess the efficacy of CRT on psychotic symptoms and cognitive complaints. Methods: We contrasted the changes in symptoms and cognitive complaints in patients with schizophrenia and related disorders who received 2 novel CRTs, one targeting mental state attribution, and the other, mental flexibility, compared with a control group given treatment as usual. Twenty-four patients with schizophrenia and related disorders were pseudo-randomly assigned to 1 of 3 groups. Psychotic symptoms and subjective complaints about their cognitive deficits were evaluated twice in each group, before and after therapy. Scores obtained pre- and post-therapy were compared between the groups. Results: The therapies were well-tolerated by the participants, and no one dropped out of the study. Symptoms decreased after therapy, but not in the control group. The mental flexibility group showed the most improvement. Moreover, patients in this group described a subjective diminution of their cognitive deficits. Conclusions: Our results demonstrate that CRT can be useful to reduce clinical symptoms while they suggest an impact of CRT on cognitive complaints in patients with schizophrenia.
AB - Background: Cognitive remediation therapy (CRT) has proven to be effective in treating cognitive deficits in schizophrenia. The current study aimed to assess the efficacy of CRT on psychotic symptoms and cognitive complaints. Methods: We contrasted the changes in symptoms and cognitive complaints in patients with schizophrenia and related disorders who received 2 novel CRTs, one targeting mental state attribution, and the other, mental flexibility, compared with a control group given treatment as usual. Twenty-four patients with schizophrenia and related disorders were pseudo-randomly assigned to 1 of 3 groups. Psychotic symptoms and subjective complaints about their cognitive deficits were evaluated twice in each group, before and after therapy. Scores obtained pre- and post-therapy were compared between the groups. Results: The therapies were well-tolerated by the participants, and no one dropped out of the study. Symptoms decreased after therapy, but not in the control group. The mental flexibility group showed the most improvement. Moreover, patients in this group described a subjective diminution of their cognitive deficits. Conclusions: Our results demonstrate that CRT can be useful to reduce clinical symptoms while they suggest an impact of CRT on cognitive complaints in patients with schizophrenia.
KW - Cognitive complaints
KW - Cognitive remediation therapy
KW - Mental state attribution
KW - Schizophrenia
KW - Symptoms
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U2 - 10.1016/j.schres.2009.03.029
DO - 10.1016/j.schres.2009.03.029
M3 - Article
C2 - 19395240
AN - SCOPUS:67349116876
SN - 0920-9964
VL - 111
SP - 153
EP - 158
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -
