Abstract
Abstract. Gallbladder storage and emptying patterns were studied in fasting normal subjects by a duodenal perfusion technique using indocyanine green as a biliary marker. Fasting gallbladder storage patterns were very variable but a more uniform biliary output with net storage of about 40% of the biliary marker was observed during a simulated interprandial state (2–4 h after meals) produced by a low dose intravenous infusion of secretin and caerulein. With this background hormonal stimulation, infusion of bovine pancreatic polypeptide to achieve physiological interprandial levels promoted further gallbladder storage of bile. Bovine pancreatic polypeptide produced storage by a major effect on the gallbladder rather than on the liver, common bile duct or sphincter of Oddi since a reduction of biliary output was not observed during bovine pancreatic polypeptide infusion in cholecystectomized subjects. Bovine pancreatic polypeptide had a separate effect on the pancreas, reducing trypsin output in both normal and cholecystectomized subjects.
Original language | English |
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Pages (from-to) | 293-300 |
Number of pages | 8 |
Journal | European Journal of Clinical Investigation |
Volume | 9 |
Issue number | 4 |
DOIs | |
Publication status | Published - Aug 1979 |
Externally published | Yes |
Keywords
- Pancreatic polypeptide
- bile salts
- biliary and pancreatic output
- caerulein
- cholecystectomy
- common bile duct
- duodenal perfusion technique
- endogenous release of human pancreatic polypeptide
- gallbladder storage
- indocyanine green
- secretin
- sphincter of Oddi
- trypsin
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry