Guinea pig neurotensin differs from other mammalian neurotensins by the substitution of proline by serine at position 7. [Ser7]neurotensin produced a concentration-dependent contraction of the guinea pig oesophagus and rat fundus, a biphasic effect (initial relaxation followed by more sustained contraction) on the guinea pig stomach corpus, duodenum and longitudinal muscle of the ileum and a relaxation of the guinea pig colon and rat ileum. The potencies (EC50) and % maximum contraction compared with the maximum effect produced by either histamine or acetylcholine of [Ser7]neurotensin and neurotensin were not significantly different in any tissue studied.
|Number of pages||4|
|Journal||European Journal of Pharmacology|
|Publication status||Published - Aug 21 1987|
- (Guinea pig)
- Gastrointestinal tract
ASJC Scopus subject areas