Effects of guinea pig neurotensin ([Ser7]neurotensin) on gastrointestinal smooth muscle

Stavros Katsoulis, J. Michael Conlon

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Guinea pig neurotensin differs from other mammalian neurotensins by the substitution of proline by serine at position 7. [Ser7]neurotensin produced a concentration-dependent contraction of the guinea pig oesophagus and rat fundus, a biphasic effect (initial relaxation followed by more sustained contraction) on the guinea pig stomach corpus, duodenum and longitudinal muscle of the ileum and a relaxation of the guinea pig colon and rat ileum. The potencies (EC50) and % maximum contraction compared with the maximum effect produced by either histamine or acetylcholine of [Ser7]neurotensin and neurotensin were not significantly different in any tissue studied.

Original languageEnglish
Pages (from-to)353-356
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number3
Publication statusPublished - Aug 21 1987
Externally publishedYes


  • (Guinea pig)
  • Gastrointestinal tract
  • Neurotensin
  • [Ser]neurotensin

ASJC Scopus subject areas

  • Pharmacology


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