Effects of guinea pig neurotensin ([Ser7]neurotensin) on gastrointestinal smooth muscle

Stavros Katsoulis; J. Michael Conlon

doi:10.1016/0014-2999(87)90293-7

Effects of guinea pig neurotensin ([Ser⁷]neurotensin) on gastrointestinal smooth muscle

Stavros Katsoulis, J. Michael Conlon

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Guinea pig neurotensin differs from other mammalian neurotensins by the substitution of proline by serine at position 7. [Ser⁷]neurotensin produced a concentration-dependent contraction of the guinea pig oesophagus and rat fundus, a biphasic effect (initial relaxation followed by more sustained contraction) on the guinea pig stomach corpus, duodenum and longitudinal muscle of the ileum and a relaxation of the guinea pig colon and rat ileum. The potencies (EC₅₀) and % maximum contraction compared with the maximum effect produced by either histamine or acetylcholine of [Ser⁷]neurotensin and neurotensin were not significantly different in any tissue studied.

Original language	English
Pages (from-to)	353-356
Number of pages	4
Journal	European Journal of Pharmacology
Volume	140
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(87)90293-7
Publication status	Published - Aug 21 1987
Externally published	Yes

Keywords

(Guinea pig)
Gastrointestinal tract
Neurotensin
[Ser]neurotensin

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0014-2999(87)90293-7

Cite this

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title = "Effects of guinea pig neurotensin ([Ser7]neurotensin) on gastrointestinal smooth muscle",

abstract = "Guinea pig neurotensin differs from other mammalian neurotensins by the substitution of proline by serine at position 7. [Ser7]neurotensin produced a concentration-dependent contraction of the guinea pig oesophagus and rat fundus, a biphasic effect (initial relaxation followed by more sustained contraction) on the guinea pig stomach corpus, duodenum and longitudinal muscle of the ileum and a relaxation of the guinea pig colon and rat ileum. The potencies (EC50) and % maximum contraction compared with the maximum effect produced by either histamine or acetylcholine of [Ser7]neurotensin and neurotensin were not significantly different in any tissue studied.",

keywords = "(Guinea pig), Gastrointestinal tract, Neurotensin, [Ser]neurotensin",

author = "Stavros Katsoulis and Conlon, {J. Michael}",

note = "Funding Information: The work was supported by the Stiftung Volkswagenwerk.",

year = "1987",

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T1 - Effects of guinea pig neurotensin ([Ser7]neurotensin) on gastrointestinal smooth muscle

AU - Katsoulis, Stavros

AU - Conlon, J. Michael

N1 - Funding Information: The work was supported by the Stiftung Volkswagenwerk.

PY - 1987/8/21

Y1 - 1987/8/21

N2 - Guinea pig neurotensin differs from other mammalian neurotensins by the substitution of proline by serine at position 7. [Ser7]neurotensin produced a concentration-dependent contraction of the guinea pig oesophagus and rat fundus, a biphasic effect (initial relaxation followed by more sustained contraction) on the guinea pig stomach corpus, duodenum and longitudinal muscle of the ileum and a relaxation of the guinea pig colon and rat ileum. The potencies (EC50) and % maximum contraction compared with the maximum effect produced by either histamine or acetylcholine of [Ser7]neurotensin and neurotensin were not significantly different in any tissue studied.

AB - Guinea pig neurotensin differs from other mammalian neurotensins by the substitution of proline by serine at position 7. [Ser7]neurotensin produced a concentration-dependent contraction of the guinea pig oesophagus and rat fundus, a biphasic effect (initial relaxation followed by more sustained contraction) on the guinea pig stomach corpus, duodenum and longitudinal muscle of the ileum and a relaxation of the guinea pig colon and rat ileum. The potencies (EC50) and % maximum contraction compared with the maximum effect produced by either histamine or acetylcholine of [Ser7]neurotensin and neurotensin were not significantly different in any tissue studied.

KW - (Guinea pig)

KW - Gastrointestinal tract

KW - Neurotensin

KW - [Ser]neurotensin

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