TY - JOUR
T1 - Effects of high-fat diet and cholecystokinin receptor blockade on promotion of pancreatic ductal cell tumors in the hamster
AU - Herrington, Margery K.
AU - Gasslander, Thomas
AU - Cina, Robert A.
AU - Fehsenfeld, Drew M.
AU - Kazakoff, Katherine R.
AU - Pour, Parviz M.
AU - Adrian, Thomas E.
N1 - Funding Information:
Devazepide was a kind gift from Dr. Victor Lotti (Merck, Sharp and Dohme, Westpoint, PA). Funding for this study was provided through National Cancer Institute Grant CA-44799 and the State of Nebraska Cancer and Smoking-Related Disease Program LB595. Address reprint requests to Dr. Thomas Adrian, Dept. of Biomédical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178.
PY - 1997
Y1 - 1997
N2 - The mechanism by which high-fat diets potentiate pancreatic cancer is not known, but pancreaticotrophic hormones such as cholecystokinin (CCK) may be involved. The effect of CCK receptor blockade on carcinogenesis during the entire promotion period was investigated in Syrian Golden hamsters fed a high- or low-fat diet and treated with N-nitrosobis(2-oxopropyl)amine (3 x 10 mg/kg at weekly intervals). One-half of the hamsters fed a high-fat diet received the CCK-A receptor antagonist devazepide (25 nmol/kg/hr) for the duration of the experiment. At 39 weeks the incidence of pancreatic malignancies was significantly higher in hamsters fed the high-fat diet than in those fed the low-fat diet (p < 0.05). Tumor incidence was not changed by CCK receptor blockade. Potentiation of pancreatic cancer by a high-fat diet in hamsters does not appear to be influenced by endogenous CCK during the tumor-promotion period.
AB - The mechanism by which high-fat diets potentiate pancreatic cancer is not known, but pancreaticotrophic hormones such as cholecystokinin (CCK) may be involved. The effect of CCK receptor blockade on carcinogenesis during the entire promotion period was investigated in Syrian Golden hamsters fed a high- or low-fat diet and treated with N-nitrosobis(2-oxopropyl)amine (3 x 10 mg/kg at weekly intervals). One-half of the hamsters fed a high-fat diet received the CCK-A receptor antagonist devazepide (25 nmol/kg/hr) for the duration of the experiment. At 39 weeks the incidence of pancreatic malignancies was significantly higher in hamsters fed the high-fat diet than in those fed the low-fat diet (p < 0.05). Tumor incidence was not changed by CCK receptor blockade. Potentiation of pancreatic cancer by a high-fat diet in hamsters does not appear to be influenced by endogenous CCK during the tumor-promotion period.
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U2 - 10.1080/01635589709514580
DO - 10.1080/01635589709514580
M3 - Article
C2 - 9343829
AN - SCOPUS:0030840582
SN - 0163-5581
VL - 28
SP - 219
EP - 224
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 3
ER -