TY - JOUR
T1 - Effects of long-term ovariectomy and ovarian steroids on somatogenic binding sites in rat brain and liver
AU - Mustafa, Amged
AU - Bogdanovic, Nenad
AU - Nyberg, Fred
AU - Suliman, Isam
AU - Islam, Atiqul
AU - Roos, Paul
AU - Winblad, Bengt
AU - Adem, Abdu
N1 - Funding Information:
The authors would like to thank the NIDDK National Hormone and Pituitary Programme for providing polypeptide hormones. This study was supported by grants from Konung Gustaf V:s och Drotting Victor& Stiftelse; The Swedish Medical Research Council; Gamla Tjlnarinnor and Hans and Loo Osterman’s Fond; Stiftel-sen Sigurd och Elsa Goljes Minne; and KI Fonder.
PY - 1995/7/21
Y1 - 1995/7/21
N2 - The effects of long-term ovariectomy and replacement with ovarian steroids on the levels of brain and liver somatogenic binding sites as well as plasma and liver growth hormone (GH) were studied in sham-operated (Sham) and ovariectomized female rats receiving either, 17β-estradiol (OVX-E), progesterone (OVX-P), or vehicle (OVX). Long-term ovariectomy decreased the levels of somatogenic binding sites in the choroid plexus and liver as well as GH in plasma and liver. The levels of these sites in the choroid plexus were partially restored only by estradiol replacement. Moreover, exogenous estradiol but not progesterone restored the levels of plasma and liver GH as well as liver somatogenic binding sites. Our results suggest that estrogens regulate the levels of somatogenic binding sites in the liver and choroid plexus.
AB - The effects of long-term ovariectomy and replacement with ovarian steroids on the levels of brain and liver somatogenic binding sites as well as plasma and liver growth hormone (GH) were studied in sham-operated (Sham) and ovariectomized female rats receiving either, 17β-estradiol (OVX-E), progesterone (OVX-P), or vehicle (OVX). Long-term ovariectomy decreased the levels of somatogenic binding sites in the choroid plexus and liver as well as GH in plasma and liver. The levels of these sites in the choroid plexus were partially restored only by estradiol replacement. Moreover, exogenous estradiol but not progesterone restored the levels of plasma and liver GH as well as liver somatogenic binding sites. Our results suggest that estrogens regulate the levels of somatogenic binding sites in the liver and choroid plexus.
KW - Growth hormone
KW - Long-term ovariectomy
KW - Ovarian steroids
KW - Rat brain
KW - Receptor autoradiography
KW - Somatogenic binding sites
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U2 - 10.1016/0304-3940(95)11759-P
DO - 10.1016/0304-3940(95)11759-P
M3 - Article
C2 - 7478236
AN - SCOPUS:0029074392
SN - 0304-3940
VL - 194
SP - 193
EP - 196
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -