Effects of peptide YY and neuropeptide Y on gastric emptying in man

J. M. Allen; M. L. Fitzpatrick; J. C. Yeats; K. Darcy; T. E. Adrian; S. R. Bloom

doi:10.1159/000199117

Effects of peptide YY and neuropeptide Y on gastric emptying in man

J. M. Allen
, M. L. Fitzpatrick
, J. C. Yeats
, K. Darcy
, T. E. Adrian
, S. R. Bloom

Research output: Contribution to journal › Article › peer-review

142 Citations (Scopus)

Abstract

Neuropeptide Y (NPY) and peptide YY (PYY) are two structurally related peptides. PYY has been identified within endocrine cells and NPY within nerves of the gastrointestinal tract. Infusion of PYY at a low dose at a nomimal rate of 2 pmol/kg/min resulted in an increment of 59.2 ± 7.1 pmol/l in plasma concentration and a significant delay in gastric emptying of glucose. Infusion of NPY at the same rate produced similar plasma concentrations (52.5 ± 1.1 pmol/l) and had no significant effect on the rate of gastric emptying.

Original language	English
Pages (from-to)	255-262
Number of pages	8
Journal	Digestion
Volume	30
Issue number	4
DOIs	https://doi.org/10.1159/000199117
Publication status	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Gastroenterology

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10.1159/000199117

Cite this

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title = "Effects of peptide YY and neuropeptide Y on gastric emptying in man",

abstract = "Neuropeptide Y (NPY) and peptide YY (PYY) are two structurally related peptides. PYY has been identified within endocrine cells and NPY within nerves of the gastrointestinal tract. Infusion of PYY at a low dose at a nomimal rate of 2 pmol/kg/min resulted in an increment of 59.2 ± 7.1 pmol/l in plasma concentration and a significant delay in gastric emptying of glucose. Infusion of NPY at the same rate produced similar plasma concentrations (52.5 ± 1.1 pmol/l) and had no significant effect on the rate of gastric emptying.",

author = "Allen, \{J. M.\} and Fitzpatrick, \{M. L.\} and Yeats, \{J. C.\} and K. Darcy and Adrian, \{T. E.\} and Bloom, \{S. R.\}",

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doi = "10.1159/000199117",

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journal = "Digestion",

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T1 - Effects of peptide YY and neuropeptide Y on gastric emptying in man

AU - Allen, J. M.

AU - Fitzpatrick, M. L.

AU - Yeats, J. C.

AU - Darcy, K.

AU - Adrian, T. E.

AU - Bloom, S. R.

PY - 1984

Y1 - 1984

N2 - Neuropeptide Y (NPY) and peptide YY (PYY) are two structurally related peptides. PYY has been identified within endocrine cells and NPY within nerves of the gastrointestinal tract. Infusion of PYY at a low dose at a nomimal rate of 2 pmol/kg/min resulted in an increment of 59.2 ± 7.1 pmol/l in plasma concentration and a significant delay in gastric emptying of glucose. Infusion of NPY at the same rate produced similar plasma concentrations (52.5 ± 1.1 pmol/l) and had no significant effect on the rate of gastric emptying.

AB - Neuropeptide Y (NPY) and peptide YY (PYY) are two structurally related peptides. PYY has been identified within endocrine cells and NPY within nerves of the gastrointestinal tract. Infusion of PYY at a low dose at a nomimal rate of 2 pmol/kg/min resulted in an increment of 59.2 ± 7.1 pmol/l in plasma concentration and a significant delay in gastric emptying of glucose. Infusion of NPY at the same rate produced similar plasma concentrations (52.5 ± 1.1 pmol/l) and had no significant effect on the rate of gastric emptying.

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SP - 255

EP - 262

JO - Digestion

JF - Digestion

IS - 4

ER -

Effects of peptide YY and neuropeptide Y on gastric emptying in man

Abstract

ASJC Scopus subject areas

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