Effects of raw soya diet and cholecystokinin receptor blockade on pancreatic growth and tumor initiation in the hamster

Margery K. Herrington; Johan Permert; Katherine R. Kazakoff; Karl A. Zucker; Anton J. Bilchik; Parviz M. Pour; Thomas E. Adrian

doi:10.1016/0304-3835(94)90140-6

Effects of raw soya diet and cholecystokinin receptor blockade on pancreatic growth and tumor initiation in the hamster

Margery K. Herrington, Johan Permert, Katherine R. Kazakoff, Karl A. Zucker, Anton J. Bilchik, Parviz M. Pour, Thomas E. Adrian

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Raw soya diet in the hamster had short-term trophic effects on the pancreas, causing significant increases in pancreatic weight, DNA, RNA, and protein. These changes appear to be mediated by cholecystokinin (CCK) because the increases were blocked by infusion of the CCK_A receptor antagonist, MK329. Raw soya diet significantly increased plasma levels of CCK in both the short-term and long-term studies. However, raw soya did not potentiate pancreatic cancer in hamsters treated with N-nitrosobis(2-oxopropyl)amine (BOP). Infusion of MK329 during the initiation period of carcinogenesis did not change tumor incidence or yield, suggesting that endogenous CCK does not influence tumor induction during the initiation period in the hamster.

Original language	English
Pages (from-to)	7-16
Number of pages	10
Journal	Cancer Letters
Volume	82
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(94)90140-6
Publication status	Published - Jul 15 1994
Externally published	Yes

Keywords

CCK
Cholecystokinin
Pancreatic cancer
Soya

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/0304-3835(94)90140-6

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title = "Effects of raw soya diet and cholecystokinin receptor blockade on pancreatic growth and tumor initiation in the hamster",

abstract = "Raw soya diet in the hamster had short-term trophic effects on the pancreas, causing significant increases in pancreatic weight, DNA, RNA, and protein. These changes appear to be mediated by cholecystokinin (CCK) because the increases were blocked by infusion of the CCKA receptor antagonist, MK329. Raw soya diet significantly increased plasma levels of CCK in both the short-term and long-term studies. However, raw soya did not potentiate pancreatic cancer in hamsters treated with N-nitrosobis(2-oxopropyl)amine (BOP). Infusion of MK329 during the initiation period of carcinogenesis did not change tumor incidence or yield, suggesting that endogenous CCK does not influence tumor induction during the initiation period in the hamster.",

keywords = "CCK, Cholecystokinin, Pancreatic cancer, Soya",

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T1 - Effects of raw soya diet and cholecystokinin receptor blockade on pancreatic growth and tumor initiation in the hamster

AU - Herrington, Margery K.

AU - Permert, Johan

AU - Kazakoff, Katherine R.

AU - Zucker, Karl A.

AU - Bilchik, Anton J.

AU - Pour, Parviz M.

AU - Adrian, Thomas E.

PY - 1994/7/15

Y1 - 1994/7/15

N2 - Raw soya diet in the hamster had short-term trophic effects on the pancreas, causing significant increases in pancreatic weight, DNA, RNA, and protein. These changes appear to be mediated by cholecystokinin (CCK) because the increases were blocked by infusion of the CCKA receptor antagonist, MK329. Raw soya diet significantly increased plasma levels of CCK in both the short-term and long-term studies. However, raw soya did not potentiate pancreatic cancer in hamsters treated with N-nitrosobis(2-oxopropyl)amine (BOP). Infusion of MK329 during the initiation period of carcinogenesis did not change tumor incidence or yield, suggesting that endogenous CCK does not influence tumor induction during the initiation period in the hamster.

AB - Raw soya diet in the hamster had short-term trophic effects on the pancreas, causing significant increases in pancreatic weight, DNA, RNA, and protein. These changes appear to be mediated by cholecystokinin (CCK) because the increases were blocked by infusion of the CCKA receptor antagonist, MK329. Raw soya diet significantly increased plasma levels of CCK in both the short-term and long-term studies. However, raw soya did not potentiate pancreatic cancer in hamsters treated with N-nitrosobis(2-oxopropyl)amine (BOP). Infusion of MK329 during the initiation period of carcinogenesis did not change tumor incidence or yield, suggesting that endogenous CCK does not influence tumor induction during the initiation period in the hamster.

KW - CCK

KW - Cholecystokinin

KW - Pancreatic cancer

KW - Soya

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Effects of raw soya diet and cholecystokinin receptor blockade on pancreatic growth and tumor initiation in the hamster

Abstract

Keywords

ASJC Scopus subject areas

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