Effects of vasoactive intestinal peptide and pancreatic polypeptide in rabbit intestine

M. Camilleri, B. T. Cooper, T. E. Adrian, S. R. Bloom, V. S. Chadwick

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The effects of porcine vasoactive intestinal peptide (VIP) and bovine pancreatic polypeptide (PP) on jejunal, ileal, and colonic fluid transport were studied in the rabbit. VIP produced secretion in the small intestine (jejunum > ileum) but did not affect absorption in the colon. PP had no secretory effects in jejunum, ileum, or colon. The small intestinal secretion induced by VIP was not associated with raised cAMP concentrations in the mucosa; this suggests that the secretory effects of VIP in vivo are mediated by a mechanism other than stimulation of adenylate cyclase.

Original languageEnglish
Pages (from-to)14-18
Number of pages5
JournalUnknown Journal
Volume22
Issue number1
DOIs
Publication statusPublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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