Effects on sperms’ quality of selegiline in aged rats

Huba Kalász; Julianna Thuróczy; Gellért Karvaly; Lajos Balogh; István Gyertyán; Edit Tóth Molnár; Ernest Adeghate; Kornélia Tekes

doi:10.2174/1874104501711010138

Effects on sperms’ quality of selegiline in aged rats

Huba Kalász, Julianna Thuróczy, Gellért Karvaly, Lajos Balogh, István Gyertyán, Edit Tóth Molnár, Ernest Adeghate, Kornélia Tekes

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Background: Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered. Objective: Scouting special and beneficial side effects of selegiline treatment. Method: Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks’ treatment. Results: Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased. Conclusion: Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.

Original language	English
Pages (from-to)	138-145
Number of pages	8
Journal	Open Medicinal Chemistry Journal
Volume	11
DOIs	https://doi.org/10.2174/1874104501711010138
Publication status	Published - Nov 1 2017

Keywords

Aged-rats
Cortisol
Dopamine
Selegiline
Semen
Sperm
Testis
Testosterone

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery

Access to Document

10.2174/1874104501711010138

Cite this

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title = "Effects on sperms{\textquoteright} quality of selegiline in aged rats",

abstract = "Background: Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered. Objective: Scouting special and beneficial side effects of selegiline treatment. Method: Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks{\textquoteright} treatment. Results: Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased. Conclusion: Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.",

keywords = "Aged-rats, Cortisol, Dopamine, Selegiline, Semen, Sperm, Testis, Testosterone",

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doi = "10.2174/1874104501711010138",

language = "English",

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AU - Kalász, Huba

AU - Thuróczy, Julianna

AU - Karvaly, Gellért

AU - Balogh, Lajos

AU - Gyertyán, István

AU - Molnár, Edit Tóth

AU - Adeghate, Ernest

AU - Tekes, Kornélia

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Background: Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered. Objective: Scouting special and beneficial side effects of selegiline treatment. Method: Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks’ treatment. Results: Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased. Conclusion: Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.

AB - Background: Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered. Objective: Scouting special and beneficial side effects of selegiline treatment. Method: Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks’ treatment. Results: Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased. Conclusion: Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.

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KW - Cortisol

KW - Dopamine

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KW - Semen

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KW - Testis

KW - Testosterone

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Effects on sperms’ quality of selegiline in aged rats

Abstract

Keywords

ASJC Scopus subject areas

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