TY - JOUR
T1 - Efficacy of marbofloxacin against respiratory infections of lambs
AU - Skoufos, J.
AU - Christodoulopoulos, G.
AU - Fragkou, I. A.
AU - Tzora, A.
AU - Gougoulis, D. A.
AU - Orfanou, D. C.
AU - Tsiolaki, K.
AU - Fthenakis, G. C.
PY - 2007/8
Y1 - 2007/8
N2 - The trial was carried out in a sheep flock with mixed Mannheimia haemolytica/Mycoplasma spp. respiratory infection; 60 lambs were included therein and allocated as follows: lambs in group MH were subcutaneously injected with marbofloxacin (3.0 mg/kg bodyweight) on two occasions, once daily 2 days apart - lambs in group ML3 were given marbofloxacin (2.0 mg/kg) on three occasion, once daily for three consecutive days - lambs in group ML2 were given marbofloxacin (2.0 mg/kg) on two occasions, 2 days apart - lambs in group T were subcutaneously injected with tilmicosin (15 mg/kg) on two occasions, 4 days apart - lambs in group C were untreated controls. The lambs were monitored before and after treatment and the clinical findings were scored; they were euthanatised 42 days after treatment for pathological examination of the lungs. Groups were similar at the start of a field trial with respect to all parameters (general clinical condition, presence of nasal discharge, presence of ophthalmic discharge, results of lung auscultation) evaluated (P > 0.05). After treatment, no systemic or local adverse reactions were observed in any lamb. Forty-two days after treatment, the median general clinical assessment score of groups MH, ML3 and T was 0, that of group ML2 was 1 and that of group C lambs was 2 (P < 0.01). Treatment with marbofloxacin was associated with improved clinical scores; the results were similar for all evaluations 14 days after treatment and subsequently. Clinical cure rate 42 days after treatment was 100, 100, 42, 100 and 0% for group MH, ML3, ML2, T and C lambs, respectively (P < 0.01). After controlling for initial weight, treatment was found to have a significant effect on carcass weight (P < 0.01). Pairwise differences in lung lesion scores between any of the four treated groups and the untreated controls were significant (P < 0.02). It is concluded that marbofloxacin is effective against respiratory infections of lambs at a dose rate of 3.0 mg/kg bodyweight given on two occasions, once daily 2 days apart or at a dose rate of 2.0 mg/kg given on three occasions for three consecutive days.
AB - The trial was carried out in a sheep flock with mixed Mannheimia haemolytica/Mycoplasma spp. respiratory infection; 60 lambs were included therein and allocated as follows: lambs in group MH were subcutaneously injected with marbofloxacin (3.0 mg/kg bodyweight) on two occasions, once daily 2 days apart - lambs in group ML3 were given marbofloxacin (2.0 mg/kg) on three occasion, once daily for three consecutive days - lambs in group ML2 were given marbofloxacin (2.0 mg/kg) on two occasions, 2 days apart - lambs in group T were subcutaneously injected with tilmicosin (15 mg/kg) on two occasions, 4 days apart - lambs in group C were untreated controls. The lambs were monitored before and after treatment and the clinical findings were scored; they were euthanatised 42 days after treatment for pathological examination of the lungs. Groups were similar at the start of a field trial with respect to all parameters (general clinical condition, presence of nasal discharge, presence of ophthalmic discharge, results of lung auscultation) evaluated (P > 0.05). After treatment, no systemic or local adverse reactions were observed in any lamb. Forty-two days after treatment, the median general clinical assessment score of groups MH, ML3 and T was 0, that of group ML2 was 1 and that of group C lambs was 2 (P < 0.01). Treatment with marbofloxacin was associated with improved clinical scores; the results were similar for all evaluations 14 days after treatment and subsequently. Clinical cure rate 42 days after treatment was 100, 100, 42, 100 and 0% for group MH, ML3, ML2, T and C lambs, respectively (P < 0.01). After controlling for initial weight, treatment was found to have a significant effect on carcass weight (P < 0.01). Pairwise differences in lung lesion scores between any of the four treated groups and the untreated controls were significant (P < 0.02). It is concluded that marbofloxacin is effective against respiratory infections of lambs at a dose rate of 3.0 mg/kg bodyweight given on two occasions, once daily 2 days apart or at a dose rate of 2.0 mg/kg given on three occasions for three consecutive days.
KW - Fluoroquinolones
KW - Mannheimia haemolytica
KW - Marbofloxacin
KW - Mycoplasma
KW - Pneumonia
KW - Sheep
UR - http://www.scopus.com/inward/record.url?scp=34250209504&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34250209504&partnerID=8YFLogxK
U2 - 10.1016/j.smallrumres.2006.07.012
DO - 10.1016/j.smallrumres.2006.07.012
M3 - Article
AN - SCOPUS:34250209504
SN - 0921-4488
VL - 71
SP - 304
EP - 309
JO - Small Ruminant Research
JF - Small Ruminant Research
IS - 1-3
ER -