Efficient allocations in group sequential tests

Toufik Zoubeidi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


We derive asymptotically efficient data dependent allocation rules for three group sequential testing procedures: Pocock (1977), O'Brien and Fleming (1979) and Falissard and Lellouch (1992). Sampling costs are defined such that the costs of observing the next group are higher than the cumulative costs of the previous groups. This formulation is used in an attempt to favor procedures that stop early while allocating less patients to the inferior treatment. We use a simulation study to compare the performances of these procedures when the efficient and the "pairwise" allocations are used. An example of applications on data is presented.

Original languageEnglish
Pages (from-to)1769-1781
Number of pages13
JournalCommunications in Statistics - Theory and Methods
Issue number8
Publication statusPublished - 1996


  • Allocation rules
  • Asymptotic efficiency
  • Clinical trials
  • Group sequential tests

ASJC Scopus subject areas

  • Statistics and Probability


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