Efficient dielectrophoretic cell enrichment using a dielectrophoresis-well based system

Mohd Azhar Abdul Razak, Kai F. Hoettges, Henry O. Fatoyinbo, Fatima H. Labeed, Michael P. Hughes

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Whilst laboratory-on-chip cell separation systems using dielectrophoresis are increasingly reported in the literature, many systems are afflicted by factors which impede "real world" performance, chief among these being cell loss (in dead spaces, attached to glass and tubing surfaces, or sedimentation from flow), and designs with large channel height-to-width ratios (large channel widths, small channel heights) that make the systems difficult to interface with other microfluidic systems. In this paper, we present a scalable structure based on 3D wells with approximately unity height-to-width ratios (based on tubes with electrodes on the sides), which is capable of enriching yeast cell populations whilst ensuring that up to 94.3% of cells processed through the device can be collected in tubes beyond the output.

Original languageEnglish
Article number064110
JournalBiomicrofluidics
Volume7
Issue number6
DOIs
Publication statusPublished - Nov 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biomedical Engineering
  • General Materials Science
  • Condensed Matter Physics
  • Fluid Flow and Transfer Processes
  • Colloid and Surface Chemistry

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