TY - JOUR
T1 - Electronic signature of DNA bases via Z-shaped graphene nanoribbon with a nanopore
AU - Wasfi, Asma
AU - Awwad, Falah
AU - Ayesh, Ahmad I.
N1 - Publisher Copyright:
© 2019 The Author(s)
PY - 2019/6/1
Y1 - 2019/6/1
N2 - DNA sequencing witnessed significant research efforts to improve its efficiency and to reduce the production cost. Successful DNA sequencing of quick and low cost techniques associate with the personalized medicine as well as procedures and the different genetics subfields of applications. In this article, a novel two-terminal z-shaped sensor is developed and studied to detect the sequence of DNA nucleobases. The z-shaped sensor consists of two metallic zigzag graphene nanoribbon (ZGNR), a semiconducting channel made of armchair graphene nanoribbon (AGNR), and a nanopore in the middle of the channel through which DNA nucleobases are translocated. First-principle modeling and non-equilibrium Green's function along with density functional theory (NEGF + DFT), are utilized to investigate the developed device. Various electronic characteristics are investigated, including transmission spectrum, conductance, and electrical current of DNA nucleobases inside the graphene sensors' nanopore. In particular, these properties are studied with variation of nucleobase orientation. The developed sensor resulted in unique signatures for the individual four DNA nucleobases placed within the nanopore.
AB - DNA sequencing witnessed significant research efforts to improve its efficiency and to reduce the production cost. Successful DNA sequencing of quick and low cost techniques associate with the personalized medicine as well as procedures and the different genetics subfields of applications. In this article, a novel two-terminal z-shaped sensor is developed and studied to detect the sequence of DNA nucleobases. The z-shaped sensor consists of two metallic zigzag graphene nanoribbon (ZGNR), a semiconducting channel made of armchair graphene nanoribbon (AGNR), and a nanopore in the middle of the channel through which DNA nucleobases are translocated. First-principle modeling and non-equilibrium Green's function along with density functional theory (NEGF + DFT), are utilized to investigate the developed device. Various electronic characteristics are investigated, including transmission spectrum, conductance, and electrical current of DNA nucleobases inside the graphene sensors' nanopore. In particular, these properties are studied with variation of nucleobase orientation. The developed sensor resulted in unique signatures for the individual four DNA nucleobases placed within the nanopore.
KW - DNA sequencing
KW - Electronic transport
KW - First principle quantum transport
KW - Graphene
KW - Nanopore
KW - Nanoribbons
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U2 - 10.1016/j.biosx.2019.100011
DO - 10.1016/j.biosx.2019.100011
M3 - Article
AN - SCOPUS:85070486021
SN - 2590-1370
VL - 1
JO - Biosensors and Bioelectronics: X
JF - Biosensors and Bioelectronics: X
M1 - 100011
ER -