TY - JOUR
T1 - Electrophysiologic mapping to determine the mechanism of experimental ventricular tachycardia initiated by premature impulses. Experimental approach and initial results demonstrating reentrant excitation
AU - Wit, Andrew L.
AU - Allessie, Maurits A.
AU - Bonke, Felix I.M.
AU - Lammers, Wim
AU - Smeets, Joep
AU - Fenoglio, John J.
N1 - Funding Information:
From the Department of Physiology, RIJksuni-versitea Limburg, Amsterdam, The Netherlands; and the Departments of Pharmacology and Pathology, College of Physicians and Surgeons of Columbia University, New York, Now York . Supported In part by Giant It 12738 from the National Heart Lug, and Blood Institute, National Institutes of Health, Bethesda, Maryland, and by Grant 13-22-24 from the Stichting vow Fundamenteel Geneeskundig Onderzoek (FUNGO), Maastricht, The Netherlands . Manuscript received June 23, 1981, accepted August 20, 1981 .
PY - 1982/1
Y1 - 1982/1
N2 - Epicardial activation patterns were determined during repetitive responses and nonsustained and sustained ventricular tachycardias induced by premature impulses in infarcted canine hearts. A multiplexing system enabled recordings to be obtained from up to 192 electrodes simultaneously either from the entire epicardial surface with a sock electrode array or only from the sheet of epicardial muscle that survives over the infarcts, with a plaque electrode array. In hearts with an infarct caused by permanent occlusion of the left anterior descending coronary artery, the earliest epicardial excitation during nonsustained tachycardias occurred on the anterior left ventricle at the border of the infarcted region and in epicardial muscle surviving over the infarcted region. Circuituous conduction patterns leading to reentry occurred in the epicardial muscle over the infarct and probably caused the arrhythmias. During sustained tachycardia in hearts with an infarct caused either by permanent or temporary occlusion of the left anterior descending coronary artery, the earliest epicardial excitation also occurred at the border of the infarcted region, but there was no evidence of reentry in the surviving epicardial muscle.
AB - Epicardial activation patterns were determined during repetitive responses and nonsustained and sustained ventricular tachycardias induced by premature impulses in infarcted canine hearts. A multiplexing system enabled recordings to be obtained from up to 192 electrodes simultaneously either from the entire epicardial surface with a sock electrode array or only from the sheet of epicardial muscle that survives over the infarcts, with a plaque electrode array. In hearts with an infarct caused by permanent occlusion of the left anterior descending coronary artery, the earliest epicardial excitation during nonsustained tachycardias occurred on the anterior left ventricle at the border of the infarcted region and in epicardial muscle surviving over the infarcted region. Circuituous conduction patterns leading to reentry occurred in the epicardial muscle over the infarct and probably caused the arrhythmias. During sustained tachycardia in hearts with an infarct caused either by permanent or temporary occlusion of the left anterior descending coronary artery, the earliest epicardial excitation also occurred at the border of the infarcted region, but there was no evidence of reentry in the surviving epicardial muscle.
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U2 - 10.1016/0002-9149(82)90292-2
DO - 10.1016/0002-9149(82)90292-2
M3 - Article
C2 - 6172033
AN - SCOPUS:0019935144
SN - 0002-9149
VL - 49
SP - 166
EP - 185
JO - The American Journal of Cardiology
JF - The American Journal of Cardiology
IS - 1
ER -