TY - JOUR
T1 - Emergence of Antibiotic Resistance in Listeria monocytogenes Isolated from Food Products
T2 - A Comprehensive Review
AU - Olaimat, Amin N.
AU - Al-Holy, Murad A.
AU - Shahbaz, Hafiz M.
AU - Al-Nabulsi, Anas A.
AU - Abu Ghoush, Mahmoud H.
AU - Osaili, Tareq M.
AU - Ayyash, Mutamed M.
AU - Holley, Richard A.
N1 - Funding Information:
The authors acknowledge financial support from the Deanship of Research at Hashemite Univ., Zarqa, Jordan.
Publisher Copyright:
© 2018 Institute of Food Technologists®
PY - 2018/9
Y1 - 2018/9
N2 - Listeria monocytogenes is an opportunistic pathogen that has been involved in several deadly illness outbreaks. Future outbreaks may be more difficult to manage because of the emergence of antibiotic resistance among L. monocytogenes strains isolated from food products. The present review summarizes the available evidence on the emergence of antibiotic resistance among L. monocytogenes strains isolated from food products and the possible ways this resistance has developed. Furthermore, the resistance of food L. monocytogenes isolates to antibiotics currently used in the treatment of human listeriosis such as penicillin, ampicillin, tetracycline, and gentamicin, has been documented. Acquisition of movable genetic elements is considered the major mechanism of antibiotic resistance development in L. monocytogenes. Efflux pumps have also been linked with resistance of L. monocytogenes to some antibiotics including fluoroquinolones. Some L. monocytogenes strains isolated from food products are intrinsically resistant to several antibiotics. However, factors in food processing chains and environments (from farm to table) including extensive or sub-inhibitory antibiotics use, horizontal gene transfer, exposure to environmental stresses, biofilm formation, and presence of persister cells play crucial roles in the development of antibiotic resistance by L. monocytogenes.
AB - Listeria monocytogenes is an opportunistic pathogen that has been involved in several deadly illness outbreaks. Future outbreaks may be more difficult to manage because of the emergence of antibiotic resistance among L. monocytogenes strains isolated from food products. The present review summarizes the available evidence on the emergence of antibiotic resistance among L. monocytogenes strains isolated from food products and the possible ways this resistance has developed. Furthermore, the resistance of food L. monocytogenes isolates to antibiotics currently used in the treatment of human listeriosis such as penicillin, ampicillin, tetracycline, and gentamicin, has been documented. Acquisition of movable genetic elements is considered the major mechanism of antibiotic resistance development in L. monocytogenes. Efflux pumps have also been linked with resistance of L. monocytogenes to some antibiotics including fluoroquinolones. Some L. monocytogenes strains isolated from food products are intrinsically resistant to several antibiotics. However, factors in food processing chains and environments (from farm to table) including extensive or sub-inhibitory antibiotics use, horizontal gene transfer, exposure to environmental stresses, biofilm formation, and presence of persister cells play crucial roles in the development of antibiotic resistance by L. monocytogenes.
KW - Listeria monocytogenes
KW - antibiotic resistance
KW - biofilm formation
KW - environmental stresses
KW - food
KW - horizontal gene transfer
KW - listeriosis
KW - multidrug resistant bacteria
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U2 - 10.1111/1541-4337.12387
DO - 10.1111/1541-4337.12387
M3 - Review article
AN - SCOPUS:85052723821
SN - 1541-4337
VL - 17
SP - 1277
EP - 1292
JO - Comprehensive Reviews in Food Science and Food Safety
JF - Comprehensive Reviews in Food Science and Food Safety
IS - 5
ER -