TY - JOUR
T1 - Emergence of multidrug-resistant Salmonella spp. and isolates with reduced susceptibility to ciprofloxacin in Kuwait and the United Arab Emirates
AU - Rotimi, Vincent O.
AU - Jamal, Wafaa
AU - Pal, Tibor
AU - Sonnevend, Agnes
AU - Dimitrov, Tsonyo S.
AU - Albert, M. John
N1 - Funding Information:
This study is supported by the Universities of Kuwait/UAE research grants, CM01/04 and no. 01-8-965-03, which are gratefully acknowledged. The authors thank Ms. Fatima Khodakhast and Ms. Refa Kuriakose, and the personnel of the Microbiology Laboratory, Tawam Hospital, Al Ain, UAE, for their technical support.
PY - 2008/1
Y1 - 2008/1
N2 - Kuwait and United Arab Emirates (UAE) are 2 countries with worldwide significance in the context of global epidemiology of antimicrobial resistance. The extent of drug resistance in Salmonella spp. isolated from these countries was investigated by determining their susceptibility to 9 antibiotics using the E-test method. Amikacin, cefotaxime, ceftriaxone, ciprofloxacin, and gentamicin had excellent activities against all Kuwait and UAE isolates with MIC90s ranging between 0.056 and 4.5 μg/mL. The resistance rates in Kuwait and UAE to ampicillin were 26.5% and 17.1%, cefotaxime/ceftriaxone 1.6% and 1.6%, ciprofloxacin 1.2% and 0.8%, chloramphenicol 5.6% and 5.7%, and trimethoprim-sulfamethoxazole 26.1% and 8.9%, respectively. A total of 9.8% of the Kuwait isolates were multidrug resistant versus 4.1% of UAE isolates. Reduced susceptibility to ciprofloxacin was observed in 14.2% and 7.4% of the nontyphoidal Salmonella, respectively, as were in 44% of Salmonella enterica serovar typhi and 66.7% Salmonella paratyphi. Salmonella spp. with reduced quinolones susceptibility have emerged in the Gulf region, and this is of concern as it may compromise the treatment of infections caused by invasive strains.
AB - Kuwait and United Arab Emirates (UAE) are 2 countries with worldwide significance in the context of global epidemiology of antimicrobial resistance. The extent of drug resistance in Salmonella spp. isolated from these countries was investigated by determining their susceptibility to 9 antibiotics using the E-test method. Amikacin, cefotaxime, ceftriaxone, ciprofloxacin, and gentamicin had excellent activities against all Kuwait and UAE isolates with MIC90s ranging between 0.056 and 4.5 μg/mL. The resistance rates in Kuwait and UAE to ampicillin were 26.5% and 17.1%, cefotaxime/ceftriaxone 1.6% and 1.6%, ciprofloxacin 1.2% and 0.8%, chloramphenicol 5.6% and 5.7%, and trimethoprim-sulfamethoxazole 26.1% and 8.9%, respectively. A total of 9.8% of the Kuwait isolates were multidrug resistant versus 4.1% of UAE isolates. Reduced susceptibility to ciprofloxacin was observed in 14.2% and 7.4% of the nontyphoidal Salmonella, respectively, as were in 44% of Salmonella enterica serovar typhi and 66.7% Salmonella paratyphi. Salmonella spp. with reduced quinolones susceptibility have emerged in the Gulf region, and this is of concern as it may compromise the treatment of infections caused by invasive strains.
KW - Ciprofloxacin
KW - Kuwait
KW - Multidrug resistance
KW - Reduced susceptibility
KW - Salmonella spp.
KW - UAE
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U2 - 10.1016/j.diagmicrobio.2007.07.007
DO - 10.1016/j.diagmicrobio.2007.07.007
M3 - Article
C2 - 17931817
AN - SCOPUS:36849075270
SN - 0732-8893
VL - 60
SP - 71
EP - 77
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 1
ER -