Abstract
Objectives: To examine the neural correlates of emotion processing in treatment-resistant patients with schizophrenia (SCZ-TR). Methods: Twenty-two SCZ-TR patients on clozapine, 24 schizophrenia patients on antipsychotics other than clozapine, and 39 healthy controls were scanned using functional neuroimaging while viewing positive, negative and neutral images. Results: Emotionally-laden images (positive and negative) elicited hyper-activations in the dorso-medial prefrontal cortex and left cerebellum in SCZ-TR patients, compared to the two other groups. Similarly, neutral images prompted hyper-activations in the cingulate gyrus in SCZ-TR patients, relative to the two other groups. Conclusions: Treatment resistance is associated with neuro-functional hyper-activations in schizophrenia patients during emotion processing.
Original language | English |
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Article number | 6499 |
Pages (from-to) | 377-380 |
Number of pages | 4 |
Journal | Schizophrenia Research |
Volume | 168 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - Oct 1 2015 |
Externally published | Yes |
Keywords
- Clozapine
- Emotion
- FMRI
- Schizophrenia
- Treatment resistance
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry