Emotion processing in treatment-resistant schizophrenia patients treated with clozapine: An fMRI study

Stéphane Potvin; Andràs Tikàsz; Ovidiu Lungu; Alexandre Dumais; Emmanuel Stip; Adrianna Mendrek

doi:10.1016/j.schres.2015.07.046

Emotion processing in treatment-resistant schizophrenia patients treated with clozapine: An fMRI study

Stéphane Potvin, Andràs Tikàsz, Ovidiu Lungu, Alexandre Dumais, Emmanuel Stip, Adrianna Mendrek

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Objectives: To examine the neural correlates of emotion processing in treatment-resistant patients with schizophrenia (SCZ-TR). Methods: Twenty-two SCZ-TR patients on clozapine, 24 schizophrenia patients on antipsychotics other than clozapine, and 39 healthy controls were scanned using functional neuroimaging while viewing positive, negative and neutral images. Results: Emotionally-laden images (positive and negative) elicited hyper-activations in the dorso-medial prefrontal cortex and left cerebellum in SCZ-TR patients, compared to the two other groups. Similarly, neutral images prompted hyper-activations in the cingulate gyrus in SCZ-TR patients, relative to the two other groups. Conclusions: Treatment resistance is associated with neuro-functional hyper-activations in schizophrenia patients during emotion processing.

Original language	English
Article number	6499
Pages (from-to)	377-380
Number of pages	4
Journal	Schizophrenia Research
Volume	168
Issue number	1-2
DOIs	https://doi.org/10.1016/j.schres.2015.07.046
Publication status	Published - Oct 1 2015
Externally published	Yes

Keywords

Clozapine
Emotion
FMRI
Schizophrenia
Treatment resistance

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.schres.2015.07.046

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title = "Emotion processing in treatment-resistant schizophrenia patients treated with clozapine: An fMRI study",

abstract = "Objectives: To examine the neural correlates of emotion processing in treatment-resistant patients with schizophrenia (SCZ-TR). Methods: Twenty-two SCZ-TR patients on clozapine, 24 schizophrenia patients on antipsychotics other than clozapine, and 39 healthy controls were scanned using functional neuroimaging while viewing positive, negative and neutral images. Results: Emotionally-laden images (positive and negative) elicited hyper-activations in the dorso-medial prefrontal cortex and left cerebellum in SCZ-TR patients, compared to the two other groups. Similarly, neutral images prompted hyper-activations in the cingulate gyrus in SCZ-TR patients, relative to the two other groups. Conclusions: Treatment resistance is associated with neuro-functional hyper-activations in schizophrenia patients during emotion processing.",

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T2 - An fMRI study

AU - Potvin, Stéphane

AU - Tikàsz, Andràs

AU - Lungu, Ovidiu

AU - Dumais, Alexandre

AU - Stip, Emmanuel

AU - Mendrek, Adrianna

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Objectives: To examine the neural correlates of emotion processing in treatment-resistant patients with schizophrenia (SCZ-TR). Methods: Twenty-two SCZ-TR patients on clozapine, 24 schizophrenia patients on antipsychotics other than clozapine, and 39 healthy controls were scanned using functional neuroimaging while viewing positive, negative and neutral images. Results: Emotionally-laden images (positive and negative) elicited hyper-activations in the dorso-medial prefrontal cortex and left cerebellum in SCZ-TR patients, compared to the two other groups. Similarly, neutral images prompted hyper-activations in the cingulate gyrus in SCZ-TR patients, relative to the two other groups. Conclusions: Treatment resistance is associated with neuro-functional hyper-activations in schizophrenia patients during emotion processing.

AB - Objectives: To examine the neural correlates of emotion processing in treatment-resistant patients with schizophrenia (SCZ-TR). Methods: Twenty-two SCZ-TR patients on clozapine, 24 schizophrenia patients on antipsychotics other than clozapine, and 39 healthy controls were scanned using functional neuroimaging while viewing positive, negative and neutral images. Results: Emotionally-laden images (positive and negative) elicited hyper-activations in the dorso-medial prefrontal cortex and left cerebellum in SCZ-TR patients, compared to the two other groups. Similarly, neutral images prompted hyper-activations in the cingulate gyrus in SCZ-TR patients, relative to the two other groups. Conclusions: Treatment resistance is associated with neuro-functional hyper-activations in schizophrenia patients during emotion processing.

KW - Clozapine

KW - Emotion

KW - FMRI

KW - Schizophrenia

KW - Treatment resistance

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Emotion processing in treatment-resistant schizophrenia patients treated with clozapine: An fMRI study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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