Emotion processing in treatment-resistant schizophrenia patients treated with clozapine: An fMRI study

Stéphane Potvin, Andràs Tikàsz, Ovidiu Lungu, Alexandre Dumais, Emmanuel Stip, Adrianna Mendrek

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Objectives: To examine the neural correlates of emotion processing in treatment-resistant patients with schizophrenia (SCZ-TR). Methods: Twenty-two SCZ-TR patients on clozapine, 24 schizophrenia patients on antipsychotics other than clozapine, and 39 healthy controls were scanned using functional neuroimaging while viewing positive, negative and neutral images. Results: Emotionally-laden images (positive and negative) elicited hyper-activations in the dorso-medial prefrontal cortex and left cerebellum in SCZ-TR patients, compared to the two other groups. Similarly, neutral images prompted hyper-activations in the cingulate gyrus in SCZ-TR patients, relative to the two other groups. Conclusions: Treatment resistance is associated with neuro-functional hyper-activations in schizophrenia patients during emotion processing.

Original languageEnglish
Article number6499
Pages (from-to)377-380
Number of pages4
JournalSchizophrenia Research
Volume168
Issue number1-2
DOIs
Publication statusPublished - Oct 1 2015
Externally publishedYes

Keywords

  • Clozapine
  • Emotion
  • FMRI
  • Schizophrenia
  • Treatment resistance

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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