TY - JOUR
T1 - Emotion processing in treatment-resistant schizophrenia patients treated with clozapine
T2 - An fMRI study
AU - Potvin, Stéphane
AU - Tikàsz, Andràs
AU - Lungu, Ovidiu
AU - Dumais, Alexandre
AU - Stip, Emmanuel
AU - Mendrek, Adrianna
N1 - Funding Information:
SP is holder of the Eli Lilly Chair on Schizophrenia Research and is supported by the Fondation de l'Institut Universitaire en Santé Mentale de Montréal ; AT was supported by a fellowship from Eli Lilly ; AD is holder of a Junior 1 grant for young investigators from the Fonds de recherche du Québec — Santé .
Funding Information:
This study was funded by the Canadian Institutes of Health Research (AM) ( MOP-81140-AM ), and by the Fondation de l'Institut Philippe-Pinel de Montréal (AD). Drs. Potvin, Lungu, Dumais, Stip, and Mendrek, as well as M. Tikàsz, reported no biomedical financial interests or potential conflicts of interest.
Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Objectives: To examine the neural correlates of emotion processing in treatment-resistant patients with schizophrenia (SCZ-TR). Methods: Twenty-two SCZ-TR patients on clozapine, 24 schizophrenia patients on antipsychotics other than clozapine, and 39 healthy controls were scanned using functional neuroimaging while viewing positive, negative and neutral images. Results: Emotionally-laden images (positive and negative) elicited hyper-activations in the dorso-medial prefrontal cortex and left cerebellum in SCZ-TR patients, compared to the two other groups. Similarly, neutral images prompted hyper-activations in the cingulate gyrus in SCZ-TR patients, relative to the two other groups. Conclusions: Treatment resistance is associated with neuro-functional hyper-activations in schizophrenia patients during emotion processing.
AB - Objectives: To examine the neural correlates of emotion processing in treatment-resistant patients with schizophrenia (SCZ-TR). Methods: Twenty-two SCZ-TR patients on clozapine, 24 schizophrenia patients on antipsychotics other than clozapine, and 39 healthy controls were scanned using functional neuroimaging while viewing positive, negative and neutral images. Results: Emotionally-laden images (positive and negative) elicited hyper-activations in the dorso-medial prefrontal cortex and left cerebellum in SCZ-TR patients, compared to the two other groups. Similarly, neutral images prompted hyper-activations in the cingulate gyrus in SCZ-TR patients, relative to the two other groups. Conclusions: Treatment resistance is associated with neuro-functional hyper-activations in schizophrenia patients during emotion processing.
KW - Clozapine
KW - Emotion
KW - FMRI
KW - Schizophrenia
KW - Treatment resistance
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U2 - 10.1016/j.schres.2015.07.046
DO - 10.1016/j.schres.2015.07.046
M3 - Article
C2 - 26255082
AN - SCOPUS:84942374280
VL - 168
SP - 377
EP - 380
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1-2
M1 - 6499
ER -
