Emotion processing in treatment-resistant schizophrenia patients treated with clozapine: An fMRI study

Stéphane Potvin; Andràs Tikàsz; Ovidiu Lungu; Alexandre Dumais; Emmanuel Stip; Adrianna Mendrek

doi:10.1016/j.schres.2015.07.046

Emotion processing in treatment-resistant schizophrenia patients treated with clozapine: An fMRI study

Stéphane Potvin
, Andràs Tikàsz
, Ovidiu Lungu
, Alexandre Dumais
, Emmanuel Stip
, Adrianna Mendrek

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Objectives: To examine the neural correlates of emotion processing in treatment-resistant patients with schizophrenia (SCZ-TR). Methods: Twenty-two SCZ-TR patients on clozapine, 24 schizophrenia patients on antipsychotics other than clozapine, and 39 healthy controls were scanned using functional neuroimaging while viewing positive, negative and neutral images. Results: Emotionally-laden images (positive and negative) elicited hyper-activations in the dorso-medial prefrontal cortex and left cerebellum in SCZ-TR patients, compared to the two other groups. Similarly, neutral images prompted hyper-activations in the cingulate gyrus in SCZ-TR patients, relative to the two other groups. Conclusions: Treatment resistance is associated with neuro-functional hyper-activations in schizophrenia patients during emotion processing.

Original language	English
Article number	6499
Pages (from-to)	377-380
Number of pages	4
Journal	Schizophrenia Research
Volume	168
Issue number	1-2
DOIs	https://doi.org/10.1016/j.schres.2015.07.046
Publication status	Published - Oct 1 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Clozapine
Emotion
FMRI
Schizophrenia
Treatment resistance

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2015.07.046

Cite this

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title = "Emotion processing in treatment-resistant schizophrenia patients treated with clozapine: An fMRI study",

abstract = "Objectives: To examine the neural correlates of emotion processing in treatment-resistant patients with schizophrenia (SCZ-TR). Methods: Twenty-two SCZ-TR patients on clozapine, 24 schizophrenia patients on antipsychotics other than clozapine, and 39 healthy controls were scanned using functional neuroimaging while viewing positive, negative and neutral images. Results: Emotionally-laden images (positive and negative) elicited hyper-activations in the dorso-medial prefrontal cortex and left cerebellum in SCZ-TR patients, compared to the two other groups. Similarly, neutral images prompted hyper-activations in the cingulate gyrus in SCZ-TR patients, relative to the two other groups. Conclusions: Treatment resistance is associated with neuro-functional hyper-activations in schizophrenia patients during emotion processing.",

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T2 - An fMRI study

AU - Potvin, Stéphane

AU - Tikàsz, Andràs

AU - Lungu, Ovidiu

AU - Dumais, Alexandre

AU - Stip, Emmanuel

AU - Mendrek, Adrianna

PY - 2015/10/1

Y1 - 2015/10/1

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KW - Clozapine

KW - Emotion

KW - FMRI

KW - Schizophrenia

KW - Treatment resistance

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Emotion processing in treatment-resistant schizophrenia patients treated with clozapine: An fMRI study

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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