Encapsulation: A Strategy to Deliver Therapeutics and Bioactive Compounds?

Iveta Klojdová, Tomáš Milota, Jitka Smetanová, Constantinos Stathopoulos

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

There is a growing demand for efficient medical therapies without undesired side effects that limit their application. Targeted therapies such as deliveries of pharmacologically active compounds to a specific site of action in the human body are still a big challenge. Encapsulation is an effective tool for targeted deliveries of drugs and sensitive compounds. It has been exploited as a technique that can manage the required distribution, action and metabolism of encapsulated agents. Food supplements or functional foods containing encapsulated probiotics, vitamins, minerals or extracts are often part of therapies and currently also a consumption trend. For effective encapsulation, optimal manufacturing has to be ensured. Thus, there is a trend to develop new (or modify existing) encapsulation methods. The most-used encapsulation approaches are based on barriers made from (bio)polymers, liposomes, multiple emulsions, etc. In this paper, recent advances in the use of encapsulation in the fields of medicine, food supplements and functional foods are highlighted, with emphasis on its benefits within targeted and supportive treatments. We have focused on a comprehensive overview of encapsulation options in the field of medicine and functional preparations that complement them with their positive effects on human health.

Original languageEnglish
Article number362
JournalPharmaceuticals
Volume16
Issue number3
DOIs
Publication statusPublished - Mar 2023
Externally publishedYes

Keywords

  • drugs
  • encapsulation
  • food supplements
  • functional foods
  • immunogenicity
  • targeted distribution of therapeutics
  • targeted therapy
  • vaccines

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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