Abstract
Using various antibodies to the amyloid β precursor protein (APP) associated with Alzheimer's disease, we investigated changes in the distribution of APP in the hippocampus and neocortex of adrenalectomized (ADX) rats. In contrast to sham-operated controls, ADX rats euthanised after a survival period of 5 months showed striking APP reactivity in the CA1-CA4 fields and in the surviving cells in the dentate gyms. Our results suggest the enhanced APP reactivity in hippocampal neurons may pertain to previous observations on the accumulation of APP fragments in the neocortex during ischemic or traumatic injury. Thus, long-term hormone deprivation would be another factor, which may influence the expression of APP in brain.
Original language | English |
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Pages (from-to) | 108-112 |
Number of pages | 5 |
Journal | Brain Research |
Volume | 806 |
Issue number | 1 |
DOIs | |
Publication status | Published - Sept 21 1998 |
Externally published | Yes |
Keywords
- Adrenalectomy
- Alzheimer's disease
- Amyloid protein precursor
- Glucocorticoid
- Hippocampus
- Vascular cell
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology