Enhancement of aflatoxin B1-induced hepatocarcinogenesis in rats by partial hepatectomy

Tahir Aziz Rizvi, Meera Mathur, Nabeen Chandra Nayak

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10 Citations (Scopus)


The effect of enhanced cell replication induced by partial hepatectomy (PH) in aflatoxin B1 (AFB1)-induced hepatocarcinogenesis has been studied in rats of the inbred As2 strain. Animals were given 0.25 mg/kg body weight of AFB1 as a single intraperitoneal dose 24 h after PH. Nonhepatectomized animals given the same dose of AFB1 served as controls. Neoplastic nodules and hepatocellular carcinoma (HCC) were detected respectively in 100% and 90% of hepatectomized animals sacrificed between 55 and 65 weeks after AFB1 administration. None of the ten non-hepatectomized rats sacrificed at this time interval showed HCC or neoplastic nodules. On histochemical staining the tumour population was found to be heterogeneous. Thus PH resulted in enhancement of AFB1-induced hepatocarcinogenesis in rats of the AS2 strain.

Original languageEnglish
Pages (from-to)345-350
Number of pages6
JournalVirchows Archiv B Cell Pathology Including Molecular Pathology
Issue number1
Publication statusPublished - Dec 1988
Externally publishedYes


  • Aflatoxin B
  • Cell replication
  • Hepatocarcinogenesis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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