Enhancement of aflatoxin B1-induced hepatocarcinogenesis in rats by partial hepatectomy

Tahir Aziz Rizvi; Meera Mathur; Nabeen Chandra Nayak

doi:10.1007/BF02890036

Enhancement of aflatoxin B₁-induced hepatocarcinogenesis in rats by partial hepatectomy

Tahir Aziz Rizvi, Meera Mathur, Nabeen Chandra Nayak

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The effect of enhanced cell replication induced by partial hepatectomy (PH) in aflatoxin B₁ (AFB₁)-induced hepatocarcinogenesis has been studied in rats of the inbred As₂ strain. Animals were given 0.25 mg/kg body weight of AFB₁ as a single intraperitoneal dose 24 h after PH. Nonhepatectomized animals given the same dose of AFB₁ served as controls. Neoplastic nodules and hepatocellular carcinoma (HCC) were detected respectively in 100% and 90% of hepatectomized animals sacrificed between 55 and 65 weeks after AFB₁ administration. None of the ten non-hepatectomized rats sacrificed at this time interval showed HCC or neoplastic nodules. On histochemical staining the tumour population was found to be heterogeneous. Thus PH resulted in enhancement of AFB₁-induced hepatocarcinogenesis in rats of the AS₂ strain.

Original language	English
Pages (from-to)	345-350
Number of pages	6
Journal	Virchows Archiv B Cell Pathology Including Molecular Pathology
Volume	56
Issue number	1
DOIs	https://doi.org/10.1007/BF02890036
Publication status	Published - Dec 1 1988
Externally published	Yes

Keywords

Aflatoxin B
Cell replication
Hepatocarcinogenesis

ASJC Scopus subject areas

Pathology and Forensic Medicine

Access to Document

10.1007/BF02890036

Cite this

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title = "Enhancement of aflatoxin B1-induced hepatocarcinogenesis in rats by partial hepatectomy",

abstract = "The effect of enhanced cell replication induced by partial hepatectomy (PH) in aflatoxin B1 (AFB1)-induced hepatocarcinogenesis has been studied in rats of the inbred As2 strain. Animals were given 0.25 mg/kg body weight of AFB1 as a single intraperitoneal dose 24 h after PH. Nonhepatectomized animals given the same dose of AFB1 served as controls. Neoplastic nodules and hepatocellular carcinoma (HCC) were detected respectively in 100% and 90% of hepatectomized animals sacrificed between 55 and 65 weeks after AFB1 administration. None of the ten non-hepatectomized rats sacrificed at this time interval showed HCC or neoplastic nodules. On histochemical staining the tumour population was found to be heterogeneous. Thus PH resulted in enhancement of AFB1-induced hepatocarcinogenesis in rats of the AS2 strain.",

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