Abstract
The effect of enhanced cell replication induced by partial hepatectomy (PH) in aflatoxin B1 (AFB1)-induced hepatocarcinogenesis has been studied in rats of the inbred As2 strain. Animals were given 0.25 mg/kg body weight of AFB1 as a single intraperitoneal dose 24 h after PH. Nonhepatectomized animals given the same dose of AFB1 served as controls. Neoplastic nodules and hepatocellular carcinoma (HCC) were detected respectively in 100% and 90% of hepatectomized animals sacrificed between 55 and 65 weeks after AFB1 administration. None of the ten non-hepatectomized rats sacrificed at this time interval showed HCC or neoplastic nodules. On histochemical staining the tumour population was found to be heterogeneous. Thus PH resulted in enhancement of AFB1-induced hepatocarcinogenesis in rats of the AS2 strain.
Original language | English |
---|---|
Pages (from-to) | 345-350 |
Number of pages | 6 |
Journal | Virchows Archiv B Cell Pathology Including Molecular Pathology |
Volume | 56 |
Issue number | 1 |
DOIs | |
Publication status | Published - Dec 1988 |
Externally published | Yes |
Keywords
- Aflatoxin B
- Cell replication
- Hepatocarcinogenesis
ASJC Scopus subject areas
- Pathology and Forensic Medicine