Epigenetic modifications in pancreas development, diabetes, and therapeutics

Suneesh Kaimala, Challagandla Anil Kumar, Mohammed Z. Allouh, Suraiya Anjum Ansari, Bright Starling Emerald

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

A recent International Diabetes Federation report suggests that more than 463 million people between 20 and 79 years have diabetes. Of the 20 million women affected by hyperglycemia during pregnancy, 84% have gestational diabetes. In addition, more than 1.1 million children or adolescents are affected by type 1 diabetes. Factors contributing to the increase in diabetes prevalence are complex and include contributions from genetic, environmental, and epigenetic factors. However, molecular regulatory mechanisms influencing the progression of an individual towards increased susceptibility to metabolic diseases such as diabetes are not fully understood. Recent studies suggest that the pathogenesis of diabetes involves epigenetic changes, resulting in a persistently dysregulated metabolic phenotype. This review summarizes the role of epigenetic mechanisms, mainly DNA methylation and histone modifications, in the development of the pancreas, their contribution to the development of diabetes, and the potential employment of epigenetic modulators in diabetes treatment.

Original languageEnglish
Pages (from-to)1343-1371
Number of pages29
JournalMedicinal Research Reviews
Volume42
Issue number3
DOIs
Publication statusPublished - May 2022

Keywords

  • DNA methylation
  • epigenetic modulators
  • gestational diabetes
  • histone modifications
  • pancreas
  • type 1 diabetes
  • type 2 diabetes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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