Estrano[17,16-e]pyrimidine-amino acid and estrano[17,16-e]pyrimidinepeptide conjugates

Tomohiro Matsumoto; Kodai Shiine; Shuntaro Mataka; Thies Thiemanna

doi:10.3184/030823409X460722

Estrano[17,16-e]pyrimidine-amino acid and estrano[17,16-e]pyrimidinepeptide conjugates

Tomohiro Matsumoto
, Kodai Shiine
, Shuntaro Mataka
, Thies Thiemanna

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Estrone has been converted to an aminopyrimidino [17,16-e]-annelated estrane derivative. A number of amino acids dipeptides and tripeptides have been linked to the aminopyrimidino unit of the annelated steroid. The tripeptide motifs may be used for the complexation of metals, such as of technetium as a radio label for the potential detection of estrogen positive breast cancer cells.

Original language	English
Pages (from-to)	391-396
Number of pages	6
Journal	Journal of Chemical Research
Issue number	6
DOIs	https://doi.org/10.3184/030823409X460722
Publication status	Published - Jun 2009

Keywords

Breast cancer
Diagnostic agents
Estranes
Steroids

ASJC Scopus subject areas

General Chemistry

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10.3184/030823409X460722

Cite this

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abstract = "Estrone has been converted to an aminopyrimidino [17,16-e]-annelated estrane derivative. A number of amino acids dipeptides and tripeptides have been linked to the aminopyrimidino unit of the annelated steroid. The tripeptide motifs may be used for the complexation of metals, such as of technetium as a radio label for the potential detection of estrogen positive breast cancer cells.",

keywords = "Breast cancer, Diagnostic agents, Estranes, Steroids",

author = "Tomohiro Matsumoto and Kodai Shiine and Shuntaro Mataka and Thies Thiemanna",

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doi = "10.3184/030823409X460722",

language = "English",

pages = "391--396",

journal = "Journal of Chemical Research",

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T1 - Estrano[17,16-e]pyrimidine-amino acid and estrano[17,16-e]pyrimidinepeptide conjugates

AU - Matsumoto, Tomohiro

AU - Shiine, Kodai

AU - Mataka, Shuntaro

AU - Thiemanna, Thies

PY - 2009/6

Y1 - 2009/6

N2 - Estrone has been converted to an aminopyrimidino [17,16-e]-annelated estrane derivative. A number of amino acids dipeptides and tripeptides have been linked to the aminopyrimidino unit of the annelated steroid. The tripeptide motifs may be used for the complexation of metals, such as of technetium as a radio label for the potential detection of estrogen positive breast cancer cells.

AB - Estrone has been converted to an aminopyrimidino [17,16-e]-annelated estrane derivative. A number of amino acids dipeptides and tripeptides have been linked to the aminopyrimidino unit of the annelated steroid. The tripeptide motifs may be used for the complexation of metals, such as of technetium as a radio label for the potential detection of estrogen positive breast cancer cells.

KW - Breast cancer

KW - Diagnostic agents

KW - Estranes

KW - Steroids

UR - https://www.scopus.com/pages/publications/68149087433

UR - https://www.scopus.com/pages/publications/68149087433#tab=citedBy

U2 - 10.3184/030823409X460722

DO - 10.3184/030823409X460722

M3 - Article

AN - SCOPUS:68149087433

SN - 0308-2342

SP - 391

EP - 396

JO - Journal of Chemical Research

JF - Journal of Chemical Research

IS - 6

ER -

Estrano[17,16-e]pyrimidine-amino acid and estrano[17,16-e]pyrimidinepeptide conjugates

Abstract

Keywords

ASJC Scopus subject areas

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