Estrano[17,16-e]pyrimidine-peptide conjugates

Tomohiro Matsumoto; Masataka Watanabe; Shuntaro Mataka; Thies Thiemann

doi:10.1016/S0039-128X(03)00145-4

Estrano[17,16-e]pyrimidine-peptide conjugates

Tomohiro Matsumoto, Masataka Watanabe, Shuntaro Mataka, Thies Thiemann

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The preparation of a steroidal heterocycle linked to the tripeptide Cys-Gly-Cys is described. Initially, an estrane-derived steroidal heterocycle containing an aminopyrimidine ring fused to the 16,17-position of the steroidal nucleus was synthesized. Thereafter, protected amino acids were coupled iteratively by the DCC method, commencing at the amino group of the aminopyrimidine unit.

Original language	English
Pages (from-to)	751-757
Number of pages	7
Journal	Steroids
Volume	68
Issue number	9
DOIs	https://doi.org/10.1016/S0039-128X(03)00145-4
Publication status	Published - Oct 2003
Externally published	Yes

Keywords

Estranes
Fused steroids
Peptides
Pyrimidines
Synthesis

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology
Pharmacology
Clinical Biochemistry
Organic Chemistry

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10.1016/S0039-128X(03)00145-4

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title = "Estrano[17,16-e]pyrimidine-peptide conjugates",

abstract = "The preparation of a steroidal heterocycle linked to the tripeptide Cys-Gly-Cys is described. Initially, an estrane-derived steroidal heterocycle containing an aminopyrimidine ring fused to the 16,17-position of the steroidal nucleus was synthesized. Thereafter, protected amino acids were coupled iteratively by the DCC method, commencing at the amino group of the aminopyrimidine unit.",

keywords = "Estranes, Fused steroids, Peptides, Pyrimidines, Synthesis",

author = "Tomohiro Matsumoto and Masataka Watanabe and Shuntaro Mataka and Thies Thiemann",

year = "2003",

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doi = "10.1016/S0039-128X(03)00145-4",

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pages = "751--757",

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T1 - Estrano[17,16-e]pyrimidine-peptide conjugates

AU - Matsumoto, Tomohiro

AU - Watanabe, Masataka

AU - Mataka, Shuntaro

AU - Thiemann, Thies

PY - 2003/10

Y1 - 2003/10

N2 - The preparation of a steroidal heterocycle linked to the tripeptide Cys-Gly-Cys is described. Initially, an estrane-derived steroidal heterocycle containing an aminopyrimidine ring fused to the 16,17-position of the steroidal nucleus was synthesized. Thereafter, protected amino acids were coupled iteratively by the DCC method, commencing at the amino group of the aminopyrimidine unit.

AB - The preparation of a steroidal heterocycle linked to the tripeptide Cys-Gly-Cys is described. Initially, an estrane-derived steroidal heterocycle containing an aminopyrimidine ring fused to the 16,17-position of the steroidal nucleus was synthesized. Thereafter, protected amino acids were coupled iteratively by the DCC method, commencing at the amino group of the aminopyrimidine unit.

KW - Estranes

KW - Fused steroids

KW - Peptides

KW - Pyrimidines

KW - Synthesis

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U2 - 10.1016/S0039-128X(03)00145-4

DO - 10.1016/S0039-128X(03)00145-4

M3 - Article

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SN - 0039-128X

VL - 68

SP - 751

EP - 757

JO - Steroids

JF - Steroids

IS - 9

ER -

Estrano[17,16-e]pyrimidine-peptide conjugates

Abstract

Keywords

ASJC Scopus subject areas

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