Estrogen receptor ligands for targeting breast tumours: A brief outlook on radioiodination strategies

Maria Cristina Oliveira, Carina Neto, Lurdes Gano, Fernanda Marques, Isabel Santos, Thies Thiemann, Ana Cristina Santos, Filomena Botelho, Carlos F. Oliveira

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

The design and development of radiolabelled estradiol derivatives has been an important area of research due to their recognized value in breast cancer management. The estrogen receptor (ER) is a relevant biomarker in the diagnosis, prognosis and prediction of the therapeutic response in estrogen receptor positive breast tumours. Hence, many radioligands based on estradiol derivatives have been proposed for targeted functional ER imaging. The main focus of this review is to survey the current knowledge on estradiol-based radioiodinated receptor ligands synthesis for breast tumour functional imaging. The main preclinical and clinical achievements in the field will also be briefly presented to make the manuscript more comprehensive.

Original languageEnglish
Pages (from-to)124-141
Number of pages18
JournalCurrent Radiopharmaceuticals
Volume5
Issue number2
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Breast cancer
  • Estradiol
  • Estrogen receptor
  • Radioiodination
  • SPECT
  • Tumor targeting

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pharmacology

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