TY - JOUR
T1 - Evaluating the forensic informativeness of mtDNA haplogroup H sub-typing on a Eurasian scale.
AU - Pereira, Luísa
AU - Richards, Martin
AU - Goios, Ana
AU - Alonso, Antonio
AU - Albarrán, Cristina
AU - Garcia, Oscar
AU - Behar, Doron M.
AU - Gölge, Mukaddes
AU - Hatina, Jiri
AU - Al-Gazali, Lihadh
AU - Bradley, Daniel G.
AU - Macaulay, Vincent
AU - Amorim, António
N1 - Funding Information:
This work was partially supported by a research grant to AG (SFRH/BD/16518/2004) from Fundação para a Ciência e a Tecnologia and IPATIMUP by Programa Operacional Ciência, Tecnologia e Inovação (POCTI), Quadro Comunitário de Apoio III. This study is included in the Project POCTI/ANT/45139/2002 financed by Fundação para a Ciência e a Tecnologia (Eixo 2, Medida 2.3 do POCTI, QCA III). We thank Pierre-Marie Danze, Dimitar Dimitrov, Peter and Anna Katharina Forster, Ariella Oppenheim, Sergei and Oksana Rychkov, and Gheorghe Stefanescu for samples and some DNA extractions.
PY - 2006/5/25
Y1 - 2006/5/25
N2 - The impact of phylogeographic information on mtDNA forensics has been limited to the quality control of published sequences and databases. In this work we use the information already available on Eurasian mtDNA phylogeography to guide the choice of coding-region SNPs for haplogroup H. This sub-typing is particularly important in forensics since, even when sequencing both HVRI and HVRII, the discriminating power is low in some Eurasian populations. We show that a small set (eight) of coding-region SNPs resolves a substantial proportion of the identical haplotypes, as defined by control-region variation alone. Moreover, this SNP set, while substantially increasing the discriminating efficiency in most Eurasian populations by roughly equal amounts, discloses population-specific profiles.
AB - The impact of phylogeographic information on mtDNA forensics has been limited to the quality control of published sequences and databases. In this work we use the information already available on Eurasian mtDNA phylogeography to guide the choice of coding-region SNPs for haplogroup H. This sub-typing is particularly important in forensics since, even when sequencing both HVRI and HVRII, the discriminating power is low in some Eurasian populations. We show that a small set (eight) of coding-region SNPs resolves a substantial proportion of the identical haplotypes, as defined by control-region variation alone. Moreover, this SNP set, while substantially increasing the discriminating efficiency in most Eurasian populations by roughly equal amounts, discloses population-specific profiles.
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U2 - 10.1016/j.forsciint.2005.06.008
DO - 10.1016/j.forsciint.2005.06.008
M3 - Article
C2 - 16076538
AN - SCOPUS:33744457967
SN - 0379-0738
VL - 159
SP - 43
EP - 50
JO - Forensic science international
JF - Forensic science international
IS - 1
ER -