Evolution: Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps

William J. Murphy; Denis M. Larkin; Annelie Everts-Van Der Wind; Guillaume Bourque; Glenn Tesler; Loretta Auvil; Jonathan E. Beever; Bhanu P. Chowdhary; Francis Galibert; Lisa Gatzke; Christophe Hitte; Stacey N. Meyers; Denis Milan; Elaine A. Ostrander; Greg Pape; Heidi G. Parker; Terje Raudsepp; Margarita B. Rogatcheva; Lawrence B. Schook; Loren C. Skow; Michael Welge; James E. Womack; Stephen J. O'Brien; Pavel A. Pevzner; Harris A. Lewin

doi:10.1126/science.1111387

Evolution: Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps

William J. Murphy, Denis M. Larkin, Annelie Everts-Van Der Wind, Guillaume Bourque, Glenn Tesler, Loretta Auvil, Jonathan E. Beever, Bhanu P. Chowdhary, Francis Galibert, Lisa Gatzke, Christophe Hitte, Stacey N. Meyers, Denis Milan, Elaine A. Ostrander, Greg Pape, Heidi G. Parker, Terje Raudsepp, Margarita B. Rogatcheva, Lawrence B. Schook, Loren C. SkowMichael Welge, James E. Womack, Stephen J. O'Brien, Pavel A. Pevzner, Harris A. Lewin

Research output: Contribution to journal › Article › peer-review

439 Citations (Scopus)

Abstract

The genome organizations of eight phylogenetically distinct species from five mammalian orders were compared in order to address fundamental questions relating to mammalian chromosomal evolution. Rates of chromosome evolution within mammalian orders were found to increase since the Cretaceous-Tertiary boundary. Nearly 20% of chromosome breakpoint regions were reused during mammalian evolution; these reuse sites are also enriched for centromeres. Analysis of gene content in and around evolutionary breakpoint regions revealed increased gene density relative to the genome-wide average. We found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement.

Original language	English
Pages (from-to)	613-617
Number of pages	5
Journal	Science
Volume	309
Issue number	5734
DOIs	https://doi.org/10.1126/science.1111387
Publication status	Published - Jul 22 2005
Externally published	Yes

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Murphy, W. J., Larkin, D. M., Everts-Van Der Wind, A., Bourque, G., Tesler, G., Auvil, L., Beever, J. E., Chowdhary, B. P., Galibert, F., Gatzke, L., Hitte, C., Meyers, S. N., Milan, D., Ostrander, E. A., Pape, G., Parker, H. G., Raudsepp, T., Rogatcheva, M. B., Schook, L. B., ... Lewin, H. A. (2005). Evolution: Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps. Science, 309(5734), 613-617. https://doi.org/10.1126/science.1111387

Murphy, WJ, Larkin, DM, Everts-Van Der Wind, A, Bourque, G, Tesler, G, Auvil, L, Beever, JE, Chowdhary, BP, Galibert, F, Gatzke, L, Hitte, C, Meyers, SN, Milan, D, Ostrander, EA, Pape, G, Parker, HG, Raudsepp, T, Rogatcheva, MB, Schook, LB, Skow, LC, Welge, M, Womack, JE, O'Brien, SJ, Pevzner, PA & Lewin, HA 2005, 'Evolution: Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps', Science, vol. 309, no. 5734, pp. 613-617. https://doi.org/10.1126/science.1111387

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title = "Evolution: Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps",

abstract = "The genome organizations of eight phylogenetically distinct species from five mammalian orders were compared in order to address fundamental questions relating to mammalian chromosomal evolution. Rates of chromosome evolution within mammalian orders were found to increase since the Cretaceous-Tertiary boundary. Nearly 20% of chromosome breakpoint regions were reused during mammalian evolution; these reuse sites are also enriched for centromeres. Analysis of gene content in and around evolutionary breakpoint regions revealed increased gene density relative to the genome-wide average. We found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement.",

author = "Murphy, {William J.} and Larkin, {Denis M.} and {Everts-Van Der Wind}, Annelie and Guillaume Bourque and Glenn Tesler and Loretta Auvil and Beever, {Jonathan E.} and Chowdhary, {Bhanu P.} and Francis Galibert and Lisa Gatzke and Christophe Hitte and Meyers, {Stacey N.} and Denis Milan and Ostrander, {Elaine A.} and Greg Pape and Parker, {Heidi G.} and Terje Raudsepp and Rogatcheva, {Margarita B.} and Schook, {Lawrence B.} and Skow, {Loren C.} and Michael Welge and Womack, {James E.} and O'Brien, {Stephen J.} and Pevzner, {Pavel A.} and Lewin, {Harris A.}",

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AU - Murphy, William J.

AU - Larkin, Denis M.

AU - Everts-Van Der Wind, Annelie

AU - Bourque, Guillaume

AU - Tesler, Glenn

AU - Auvil, Loretta

AU - Beever, Jonathan E.

AU - Chowdhary, Bhanu P.

AU - Galibert, Francis

AU - Gatzke, Lisa

AU - Hitte, Christophe

AU - Meyers, Stacey N.

AU - Milan, Denis

AU - Ostrander, Elaine A.

AU - Pape, Greg

AU - Parker, Heidi G.

AU - Raudsepp, Terje

AU - Rogatcheva, Margarita B.

AU - Schook, Lawrence B.

AU - Skow, Loren C.

AU - Welge, Michael

AU - Womack, James E.

AU - O'Brien, Stephen J.

AU - Pevzner, Pavel A.

AU - Lewin, Harris A.

PY - 2005/7/22

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N2 - The genome organizations of eight phylogenetically distinct species from five mammalian orders were compared in order to address fundamental questions relating to mammalian chromosomal evolution. Rates of chromosome evolution within mammalian orders were found to increase since the Cretaceous-Tertiary boundary. Nearly 20% of chromosome breakpoint regions were reused during mammalian evolution; these reuse sites are also enriched for centromeres. Analysis of gene content in and around evolutionary breakpoint regions revealed increased gene density relative to the genome-wide average. We found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement.

AB - The genome organizations of eight phylogenetically distinct species from five mammalian orders were compared in order to address fundamental questions relating to mammalian chromosomal evolution. Rates of chromosome evolution within mammalian orders were found to increase since the Cretaceous-Tertiary boundary. Nearly 20% of chromosome breakpoint regions were reused during mammalian evolution; these reuse sites are also enriched for centromeres. Analysis of gene content in and around evolutionary breakpoint regions revealed increased gene density relative to the genome-wide average. We found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement.

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Evolution: Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps

Abstract

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