TY - JOUR
T1 - Exogenous glutamate induces short and long-term potentiation in the rat medial vestibular nuclei
AU - Grassi, Silvarosa
AU - Frondaroli, Adele
AU - Pessia, Mauro
AU - Pettorossi, Vito Enrico
PY - 2001/8/8
Y1 - 2001/8/8
N2 - In rat brain stem slices, high concentrations of exogenous glutamate induce long-term potentiation (LTP) of the field potentials evoked in the medial vestibular nuclei (MVN) by vestibular afferent stimulation. At low concentrations, glutamate can also induce short-term potentiation (STP), indicating that LTP and STP are separate events depending on the level of glutamatergic synapse activation. LTP and STP are prevented by blocking NMDA receptors and nitric oxide (NO) synthesis. Conversely, blocking platelet-activating factor (PAF) and group I metabotropic glutamate receptors only prevents the full development of LTP. Moreover, in the presence of blocking agents, glutamate causes transient inhibition, suggesting that when potentiation is impeded, exogenous glutamate can activate presynaptic mechanisms that reduce glutamate release.
AB - In rat brain stem slices, high concentrations of exogenous glutamate induce long-term potentiation (LTP) of the field potentials evoked in the medial vestibular nuclei (MVN) by vestibular afferent stimulation. At low concentrations, glutamate can also induce short-term potentiation (STP), indicating that LTP and STP are separate events depending on the level of glutamatergic synapse activation. LTP and STP are prevented by blocking NMDA receptors and nitric oxide (NO) synthesis. Conversely, blocking platelet-activating factor (PAF) and group I metabotropic glutamate receptors only prevents the full development of LTP. Moreover, in the presence of blocking agents, glutamate causes transient inhibition, suggesting that when potentiation is impeded, exogenous glutamate can activate presynaptic mechanisms that reduce glutamate release.
KW - Exogenous glutamate
KW - Field potential
KW - Long-term potentiation
KW - Medial vestibular nuclei
KW - Short-term potentiation
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U2 - 10.1097/00001756-200108080-00010
DO - 10.1097/00001756-200108080-00010
M3 - Article
C2 - 11496105
AN - SCOPUS:0035828167
SN - 0959-4965
VL - 12
SP - 2329
EP - 2334
JO - NeuroReport
JF - NeuroReport
IS - 11
ER -