TY - JOUR
T1 - Expansion of large granular lymphocytes (natural killer cells) with limited antigen expression (CD2+, CD3−, CD4−, CD8−, CD16+, NKH−1‐) in a human immunodeficiency virus‐positive homosexual man
AU - Ghali, Violette
AU - Castella, Antonio
AU - Louis‐Charles, Anthony
AU - Agranovsky, Elena
AU - Croxson, Scott T.
PY - 1990/5/15
Y1 - 1990/5/15
N2 - Lymphoid neoplasms associated with acquired immune deficiency syndrome (AIDS) are mostly of B‐cell type and rarely of T‐cell origin. The authors report a case of a homosexual HIV antibody‐positive, HTLV‐1 antibody‐negative man who developed T‐lymphoproliferative disorder (TGLD) after he experienced a viral‐like illness. The lymphoproliferative disorder was characterized by increased peripheral blood large granular lymphocytes (LGL) with azurophilic granules (natural killer [NK] cells) which had limited antigen expression: CD2+, CD3−, CD4−, CD8−, CD16+, NKH−1−. The LGL failed to express T‐cell or T‐cell‐related antigens, with the exception of CD2. No functional or gene rearrangement studies were performed on the patient's lymphocytes. However, the results of immunophenotyping, including CD25, W26, and HLA‐DR, were suggestive of an inactive state, and the negative finding for CD3 antigen was consistent with unarranged gene T‐cell receptors. This is the first reported case of TGLD in an HIV antibody‐positive patient.
AB - Lymphoid neoplasms associated with acquired immune deficiency syndrome (AIDS) are mostly of B‐cell type and rarely of T‐cell origin. The authors report a case of a homosexual HIV antibody‐positive, HTLV‐1 antibody‐negative man who developed T‐lymphoproliferative disorder (TGLD) after he experienced a viral‐like illness. The lymphoproliferative disorder was characterized by increased peripheral blood large granular lymphocytes (LGL) with azurophilic granules (natural killer [NK] cells) which had limited antigen expression: CD2+, CD3−, CD4−, CD8−, CD16+, NKH−1−. The LGL failed to express T‐cell or T‐cell‐related antigens, with the exception of CD2. No functional or gene rearrangement studies were performed on the patient's lymphocytes. However, the results of immunophenotyping, including CD25, W26, and HLA‐DR, were suggestive of an inactive state, and the negative finding for CD3 antigen was consistent with unarranged gene T‐cell receptors. This is the first reported case of TGLD in an HIV antibody‐positive patient.
UR - http://www.scopus.com/inward/record.url?scp=0025348697&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025348697&partnerID=8YFLogxK
U2 - 10.1002/1097-0142(19900515)65:10<2243::AID-CNCR2820651014>3.0.CO;2-D
DO - 10.1002/1097-0142(19900515)65:10<2243::AID-CNCR2820651014>3.0.CO;2-D
M3 - Article
C2 - 2346908
AN - SCOPUS:0025348697
SN - 0008-543X
VL - 65
SP - 2243
EP - 2247
JO - Cancer
JF - Cancer
IS - 10
ER -