Exploring the untapped pharmacological potential of imidazopyridazines

M. Shaheer Malik, Hossa F. Alshareef, Khalid A. Alfaidi, Hissana Ather, Zainularifeen Abduljaleel, Essam M. Hussein, Ziad Moussa, Saleh A. Ahmed

Research output: Contribution to journalReview articlepeer-review

Abstract

Imidazopyridazines are fused heterocycles, like purines, with a pyridazine ring replacing the pyrimidine ring in purines. Imidazopyridazines have been primarily studied for their kinase inhibition activity in the development of new anticancer and antimalarial agents. In addition to this, they have also been investigated for their anticonvulsant, antiallergic, antihistamine, antiviral, and antitubercular properties. Herein, we review the background and development of different imidazopyridazines as potential pharmacological agents. Moreover, the scope of this relatively less charted heterocyclic scaffold is also highlighted.

Original languageEnglish
Pages (from-to)3972-3984
Number of pages13
JournalRSC Advances
Volume14
Issue number6
DOIs
Publication statusPublished - Jan 29 2024

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering

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