Exploring the untapped pharmacological potential of imidazopyridazines

M. Shaheer Malik; Hossa F. Alshareef; Khalid A. Alfaidi; Hissana Ather; Zainularifeen Abduljaleel; Essam M. Hussein; Ziad Moussa; Saleh A. Ahmed

doi:10.1039/d3ra07280k

Exploring the untapped pharmacological potential of imidazopyridazines

M. Shaheer Malik, Hossa F. Alshareef, Khalid A. Alfaidi, Hissana Ather, Zainularifeen Abduljaleel, Essam M. Hussein, Ziad Moussa, Saleh A. Ahmed

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Imidazopyridazines are fused heterocycles, like purines, with a pyridazine ring replacing the pyrimidine ring in purines. Imidazopyridazines have been primarily studied for their kinase inhibition activity in the development of new anticancer and antimalarial agents. In addition to this, they have also been investigated for their anticonvulsant, antiallergic, antihistamine, antiviral, and antitubercular properties. Herein, we review the background and development of different imidazopyridazines as potential pharmacological agents. Moreover, the scope of this relatively less charted heterocyclic scaffold is also highlighted.

Original language	English
Pages (from-to)	3972-3984
Number of pages	13
Journal	RSC Advances
Volume	14
Issue number	6
DOIs	https://doi.org/10.1039/d3ra07280k
Publication status	Published - Jan 29 2024

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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abstract = "Imidazopyridazines are fused heterocycles, like purines, with a pyridazine ring replacing the pyrimidine ring in purines. Imidazopyridazines have been primarily studied for their kinase inhibition activity in the development of new anticancer and antimalarial agents. In addition to this, they have also been investigated for their anticonvulsant, antiallergic, antihistamine, antiviral, and antitubercular properties. Herein, we review the background and development of different imidazopyridazines as potential pharmacological agents. Moreover, the scope of this relatively less charted heterocyclic scaffold is also highlighted.",

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AU - Malik, M. Shaheer

AU - Alshareef, Hossa F.

AU - Alfaidi, Khalid A.

AU - Ather, Hissana

AU - Abduljaleel, Zainularifeen

AU - Hussein, Essam M.

AU - Moussa, Ziad

AU - Ahmed, Saleh A.

PY - 2024/1/29

Y1 - 2024/1/29

N2 - Imidazopyridazines are fused heterocycles, like purines, with a pyridazine ring replacing the pyrimidine ring in purines. Imidazopyridazines have been primarily studied for their kinase inhibition activity in the development of new anticancer and antimalarial agents. In addition to this, they have also been investigated for their anticonvulsant, antiallergic, antihistamine, antiviral, and antitubercular properties. Herein, we review the background and development of different imidazopyridazines as potential pharmacological agents. Moreover, the scope of this relatively less charted heterocyclic scaffold is also highlighted.

AB - Imidazopyridazines are fused heterocycles, like purines, with a pyridazine ring replacing the pyrimidine ring in purines. Imidazopyridazines have been primarily studied for their kinase inhibition activity in the development of new anticancer and antimalarial agents. In addition to this, they have also been investigated for their anticonvulsant, antiallergic, antihistamine, antiviral, and antitubercular properties. Herein, we review the background and development of different imidazopyridazines as potential pharmacological agents. Moreover, the scope of this relatively less charted heterocyclic scaffold is also highlighted.

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Exploring the untapped pharmacological potential of imidazopyridazines

Abstract

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