Extraneural cholinergic markers in Alzheimer's and Parkinson's disease

Abdu Adem, Agneta Nordberg, Gösta Bucht, Bengt Winblad

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Adem, Abdu, Agneta Nordberg, Gösta Bucht and Bengt Winblad: Extraneural cholinergic markers in Alzheimer's and Parkinson's disease. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1986, 10 (3-5): 247-257. 1. 1. Muscarinic and nicotinic binding sites were analysed in lymphocytes from patients with Alzheimer's disease, Multi-infarct dementia, Parkinson's disease and age- matched controls. 2. 2. A significant decrease in the number of both muscarinic and nicotinic binding sites was obtained in lymphocytes from Alzheimer patients while in Parkinson patients a significant decrease was found only in the nicotinic binding sites. 3. 3. Using butyrylthiocholine as substrate, no change was observed in cholinesterase activity in plasma from Alzheimer patients, whereas a significant decrease in plasma cholinesterase activity was found in Parkinson patients.

Original languageEnglish
Pages (from-to)247-257
Number of pages11
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Issue number3-5
Publication statusPublished - 1986
Externally publishedYes


  • Alzheimer's disease
  • Multi-infarct dementia
  • Parkinson's disease
  • choline acetyltransferase
  • cholinesterase
  • muscarinic receptors
  • nicotinic receptors

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry


Dive into the research topics of 'Extraneural cholinergic markers in Alzheimer's and Parkinson's disease'. Together they form a unique fingerprint.

Cite this