Fast and efficient microwave synthetic methods for some new 2(1H)-pyridone arabinosides

Two series of novel 3-cyano-2-(2'' ,3'' ,4'' -tri- O - acetyl- β - d -arabinopyranosyloxy)pyridones 5a - h and 9a,b were synthesized. Microwave irradiation has been used to obtain these products in high yield under milder conditions by the reaction of 2(1 H )-pyridone or its salt with an activated arabinose. The silyl method was used to obtain the same nucleosides 5a - h and 9a,b . Triethylamine was used to remove the acetyl protecting groups from the sugar moiety and to produce the free nucleosides 6a - h and 10a,b in 85 - 91% yield.