Abstract
Transplantation is the proven treatment for acute liver failure and in severe cases, affective Bioartificial Liver (BAL) support may provide a bridge to transplantation. This paper describes in vitro evaluation of a novel Fibre-in-Fibre BAL. It is a conventional fibre cartridge with three discrete compartments. Bovine blood is used to assess Oxygen transfer performance of the FIF bioreactor. The tests were carried according to ISO test protocols. Blood flow rate, number of fibre-in-fibre pairs and haemoglobin concentration, CHb are used to assess the oxygen transfer rates. The results demonstrated that the FIF bioreactor provides good gas transfer support.
Original language | English |
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Pages (from-to) | 323-326 |
Number of pages | 4 |
Journal | International Journal of Biomedical Engineering and Technology |
Volume | 6 |
Issue number | 4 |
DOIs | |
Publication status | Published - Aug 2011 |
Keywords
- Artificial liver
- FIF-BAL
- Fibre-in-Fibre BAL
- Hepatocytes
- Hybrid liver support
- Liver failure
- Therapies
ASJC Scopus subject areas
- Biomedical Engineering