Fibre-in-Fibre Bioartificial Liver device: Initial in vitro testing

Ali Hilal-Alnaqbi, John D.S. Gaylor

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Transplantation is the proven treatment for acute liver failure and in severe cases, affective Bioartificial Liver (BAL) support may provide a bridge to transplantation. This paper describes in vitro evaluation of a novel Fibre-in-Fibre BAL. It is a conventional fibre cartridge with three discrete compartments. Bovine blood is used to assess Oxygen transfer performance of the FIF bioreactor. The tests were carried according to ISO test protocols. Blood flow rate, number of fibre-in-fibre pairs and haemoglobin concentration, CHb are used to assess the oxygen transfer rates. The results demonstrated that the FIF bioreactor provides good gas transfer support.

Original languageEnglish
Pages (from-to)323-326
Number of pages4
JournalInternational Journal of Biomedical Engineering and Technology
Issue number4
Publication statusPublished - Aug 2011


  • Artificial liver
  • Fibre-in-Fibre BAL
  • Hepatocytes
  • Hybrid liver support
  • Liver failure
  • Therapies

ASJC Scopus subject areas

  • Biomedical Engineering


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