Fibre-in-Fibre Bioartificial Liver device: Initial in vitro testing

Ali Hilal-Alnaqbi; John D.S. Gaylor

doi:10.1504/IJBET.2011.041771

Fibre-in-Fibre Bioartificial Liver device: Initial in vitro testing

Ali Hilal-Alnaqbi, John D.S. Gaylor

Department of Mechanical and Aerospace Engineering

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Transplantation is the proven treatment for acute liver failure and in severe cases, affective Bioartificial Liver (BAL) support may provide a bridge to transplantation. This paper describes in vitro evaluation of a novel Fibre-in-Fibre BAL. It is a conventional fibre cartridge with three discrete compartments. Bovine blood is used to assess Oxygen transfer performance of the FIF bioreactor. The tests were carried according to ISO test protocols. Blood flow rate, number of fibre-in-fibre pairs and haemoglobin concentration, CHb are used to assess the oxygen transfer rates. The results demonstrated that the FIF bioreactor provides good gas transfer support.

Original language	English
Pages (from-to)	323-326
Number of pages	4
Journal	International Journal of Biomedical Engineering and Technology
Volume	6
Issue number	4
DOIs	https://doi.org/10.1504/IJBET.2011.041771
Publication status	Published - Aug 2011

Keywords

Artificial liver
FIF-BAL
Fibre-in-Fibre BAL
Hepatocytes
Hybrid liver support
Liver failure
Therapies

ASJC Scopus subject areas

Biomedical Engineering

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10.1504/IJBET.2011.041771

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title = "Fibre-in-Fibre Bioartificial Liver device: Initial in vitro testing",

abstract = "Transplantation is the proven treatment for acute liver failure and in severe cases, affective Bioartificial Liver (BAL) support may provide a bridge to transplantation. This paper describes in vitro evaluation of a novel Fibre-in-Fibre BAL. It is a conventional fibre cartridge with three discrete compartments. Bovine blood is used to assess Oxygen transfer performance of the FIF bioreactor. The tests were carried according to ISO test protocols. Blood flow rate, number of fibre-in-fibre pairs and haemoglobin concentration, CHb are used to assess the oxygen transfer rates. The results demonstrated that the FIF bioreactor provides good gas transfer support.",

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AB - Transplantation is the proven treatment for acute liver failure and in severe cases, affective Bioartificial Liver (BAL) support may provide a bridge to transplantation. This paper describes in vitro evaluation of a novel Fibre-in-Fibre BAL. It is a conventional fibre cartridge with three discrete compartments. Bovine blood is used to assess Oxygen transfer performance of the FIF bioreactor. The tests were carried according to ISO test protocols. Blood flow rate, number of fibre-in-fibre pairs and haemoglobin concentration, CHb are used to assess the oxygen transfer rates. The results demonstrated that the FIF bioreactor provides good gas transfer support.

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Fibre-in-Fibre Bioartificial Liver device: Initial in vitro testing

Abstract

Keywords

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