Fibrillary glomerulonephritis with anti-glomerular basement membrane antibody: A combined glomerular insult

Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome characterized by quick and propagative deterioration of renal function with loosing 50% or more of renal function within three months. RGPN is associated with cellular crescents in more than 50% of glomeruli; hence it is called crescentic glomerulonephritis. We report a 47-year-old patient who presents with RPGN associated with fibrillary glomerulonephritis (FGN) and positive antiglomerular basement membrane (anti-GBM) antibody. In conclusion, FGN should be suspected in any case of RPGN presents with a nephrotic range of proteinuria. Although light microscopic and immunofluorescent studies in a renal biopsy are essential, electron microscopic study is the gold standard in establishing the diagnosis of FGN. FGN and Anti-GBM disease can co-exist as causes of RPGN.