FISH mapping of the IGF2 gene in horse and donkey - Detection of homoeology with HSA11

Terje Raudsepp, Kerstin Otte, Björn Rozell, Bhanu P. Chowdhary

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Three genomic subclones derived from a phage clone containing the equine IGF2 gene were used to FISH map the gene on horse (ECA) and donkey (EAS) metaphase chromosomes. The gene mapped on ECA 12q13 band and is the first locus mapped to this horse chromosome. In donkey the gene mapped very terminal on the long arm of one small submetacentric chromosome that shows almost identical DAPI-banding pattern with ECA12. This is the first locus mapped in donkey genome. Cross species chromosome painting of equine metaphase chromosomes with human Chromosome (Chr) 11-specific probe showed homoeology of this human chromosome with ECA12 and ECA7. The novel ECA12 comparative painting results are thus in accordance with the localization of the equine IGF2 gene. Comparison of the hitherto known physical locations of IGF2 in different species, viz. human, cattle, sheep, horse, and donkey, shows that this gene tends to maintain a terminal location on the chromosome arm.

Original languageEnglish
Pages (from-to)569-572
Number of pages4
JournalMammalian Genome
Issue number8
Publication statusPublished - Aug 1997
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


Dive into the research topics of 'FISH mapping of the IGF2 gene in horse and donkey - Detection of homoeology with HSA11'. Together they form a unique fingerprint.

Cite this