Flavonoids and related privileged scaffolds as potential urease inhibitors: a review

Munirah M. Al-Rooqi, Ehsan Ullah Mughal, Qandeel Alam Raja, Essam M. Hussein, Nafeesa Naeem, Amina Sadiq, Basim H. Asghar, Ziad Moussa, Saleh A. Ahmed

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Infections caused by bacteria are a significant issue on a global scale, and imperative action is required to discover novel or improved therapeutic agents. Flavonoids are a class of plant-derived compounds that have a variety of potentially useful bioactivities. These activities include immediate antimicrobial properties, synergistic effect with antimicrobials, ferocious repression of pathogenicity, anti-urease activity etc. This review summarizes current studies concerning anti-urease actions of flavonoids as well as structural-activity correlation investigations of the flavonoid core structure. It is possible that if researchers investigate the many structural changes that may be made in flavonoid rings, they'll be able to build up novel compounds that have powerful and effective anti-urease properties.

Original languageEnglish
Pages (from-to)3210-3233
Number of pages24
JournalRSC Advances
Volume13
Issue number5
DOIs
Publication statusPublished - Jan 23 2023

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering

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