Flavonoids and related privileged scaffolds as potential urease inhibitors: a review

Munirah M. Al-Rooqi; Ehsan Ullah Mughal; Qandeel Alam Raja; Essam M. Hussein; Nafeesa Naeem; Amina Sadiq; Basim H. Asghar; Ziad Moussa; Saleh A. Ahmed

doi:10.1039/d2ra08284e

Flavonoids and related privileged scaffolds as potential urease inhibitors: a review

Munirah M. Al-Rooqi, Ehsan Ullah Mughal, Qandeel Alam Raja, Essam M. Hussein, Nafeesa Naeem, Amina Sadiq, Basim H. Asghar, Ziad Moussa, Saleh A. Ahmed

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

Abstract

Infections caused by bacteria are a significant issue on a global scale, and imperative action is required to discover novel or improved therapeutic agents. Flavonoids are a class of plant-derived compounds that have a variety of potentially useful bioactivities. These activities include immediate antimicrobial properties, synergistic effect with antimicrobials, ferocious repression of pathogenicity, anti-urease activity etc. This review summarizes current studies concerning anti-urease actions of flavonoids as well as structural-activity correlation investigations of the flavonoid core structure. It is possible that if researchers investigate the many structural changes that may be made in flavonoid rings, they'll be able to build up novel compounds that have powerful and effective anti-urease properties.

Original language	English
Pages (from-to)	3210-3233
Number of pages	24
Journal	RSC Advances
Volume	13
Issue number	5
DOIs	https://doi.org/10.1039/d2ra08284e
Publication status	Published - Jan 23 2023

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)

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10.1039/d2ra08284e

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title = "Flavonoids and related privileged scaffolds as potential urease inhibitors: a review",

abstract = "Infections caused by bacteria are a significant issue on a global scale, and imperative action is required to discover novel or improved therapeutic agents. Flavonoids are a class of plant-derived compounds that have a variety of potentially useful bioactivities. These activities include immediate antimicrobial properties, synergistic effect with antimicrobials, ferocious repression of pathogenicity, anti-urease activity etc. This review summarizes current studies concerning anti-urease actions of flavonoids as well as structural-activity correlation investigations of the flavonoid core structure. It is possible that if researchers investigate the many structural changes that may be made in flavonoid rings, they'll be able to build up novel compounds that have powerful and effective anti-urease properties.",

author = "Al-Rooqi, {Munirah M.} and Mughal, {Ehsan Ullah} and Raja, {Qandeel Alam} and Hussein, {Essam M.} and Nafeesa Naeem and Amina Sadiq and Asghar, {Basim H.} and Ziad Moussa and Ahmed, {Saleh A.}",

note = "Funding Information: The authors would like to acknowledge the Deanship of Scientific Research at Umm Al-Qura University, for supporting this work by grant code: 22UQU4220005DSR01. Dr Ziad Moussa is grateful to the United Arab Emirates University (UAEU) and to the Research Office for supporting the research developed in his laboratory and reported herein (SUREPLUS grant code G00003918). The financial support by the Higher Education Commission of Pakistan (HEC) under project no. NRPU-15800 is also gratefully acknowledged. Publisher Copyright: {\textcopyright} 2023 The Royal Society of Chemistry.",

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T1 - Flavonoids and related privileged scaffolds as potential urease inhibitors

T2 - a review

AU - Al-Rooqi, Munirah M.

AU - Mughal, Ehsan Ullah

AU - Raja, Qandeel Alam

AU - Hussein, Essam M.

AU - Naeem, Nafeesa

AU - Sadiq, Amina

AU - Asghar, Basim H.

AU - Moussa, Ziad

AU - Ahmed, Saleh A.

N1 - Funding Information: The authors would like to acknowledge the Deanship of Scientific Research at Umm Al-Qura University, for supporting this work by grant code: 22UQU4220005DSR01. Dr Ziad Moussa is grateful to the United Arab Emirates University (UAEU) and to the Research Office for supporting the research developed in his laboratory and reported herein (SUREPLUS grant code G00003918). The financial support by the Higher Education Commission of Pakistan (HEC) under project no. NRPU-15800 is also gratefully acknowledged. Publisher Copyright: © 2023 The Royal Society of Chemistry.

PY - 2023/1/23

Y1 - 2023/1/23

N2 - Infections caused by bacteria are a significant issue on a global scale, and imperative action is required to discover novel or improved therapeutic agents. Flavonoids are a class of plant-derived compounds that have a variety of potentially useful bioactivities. These activities include immediate antimicrobial properties, synergistic effect with antimicrobials, ferocious repression of pathogenicity, anti-urease activity etc. This review summarizes current studies concerning anti-urease actions of flavonoids as well as structural-activity correlation investigations of the flavonoid core structure. It is possible that if researchers investigate the many structural changes that may be made in flavonoid rings, they'll be able to build up novel compounds that have powerful and effective anti-urease properties.

AB - Infections caused by bacteria are a significant issue on a global scale, and imperative action is required to discover novel or improved therapeutic agents. Flavonoids are a class of plant-derived compounds that have a variety of potentially useful bioactivities. These activities include immediate antimicrobial properties, synergistic effect with antimicrobials, ferocious repression of pathogenicity, anti-urease activity etc. This review summarizes current studies concerning anti-urease actions of flavonoids as well as structural-activity correlation investigations of the flavonoid core structure. It is possible that if researchers investigate the many structural changes that may be made in flavonoid rings, they'll be able to build up novel compounds that have powerful and effective anti-urease properties.

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Flavonoids and related privileged scaffolds as potential urease inhibitors: a review

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