Fluorinated steroids and their derivatives

Yosef Al Jasem; Thies Thiemann; Lurdes Gano; Maria Cristina Oliveira

doi:10.1016/j.jfluchem.2016.03.009

Fluorinated steroids and their derivatives

Yosef Al Jasem, Thies Thiemann, Lurdes Gano, Maria Cristina Oliveira

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

14 Citations (Scopus)

Abstract

Fluorinated steroids have found entry into the list of important pharmaceuticals. Fluorinated corticosteroids are being used as topical drugs against rheumatism and inflammatory skin diseases or as inhalation drugs again asthma. A number of fluorinated steroids bind strongly to the estrogen or the progesterone receptor. With the availability of [¹⁸F]fluorine as a radiolabel, radiofluorinated steroids are being developed as potential positron emission tomography (PET) imaging agents. This article presents an overview of preparative methods to fluorinated steroids as well as of the uses of these compounds.

Original language	English
Pages (from-to)	48-85
Number of pages	38
Journal	Journal of Fluorine Chemistry
Volume	185
DOIs	https://doi.org/10.1016/j.jfluchem.2016.03.009
Publication status	Published - May 1 2016

Keywords

Corticosteroids
Estrogen receptor ligands
Fluorination
Positron emission tomography (PET)
Radiolabelling

ASJC Scopus subject areas

Biochemistry
Environmental Chemistry
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.1016/j.jfluchem.2016.03.009

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title = "Fluorinated steroids and their derivatives",

abstract = "Fluorinated steroids have found entry into the list of important pharmaceuticals. Fluorinated corticosteroids are being used as topical drugs against rheumatism and inflammatory skin diseases or as inhalation drugs again asthma. A number of fluorinated steroids bind strongly to the estrogen or the progesterone receptor. With the availability of [18F]fluorine as a radiolabel, radiofluorinated steroids are being developed as potential positron emission tomography (PET) imaging agents. This article presents an overview of preparative methods to fluorinated steroids as well as of the uses of these compounds.",

keywords = "Corticosteroids, Estrogen receptor ligands, Fluorination, Positron emission tomography (PET), Radiolabelling",

author = "Jasem, {Yosef Al} and Thies Thiemann and Lurdes Gano and Oliveira, {Maria Cristina}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier B.V.",

year = "2016",

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doi = "10.1016/j.jfluchem.2016.03.009",

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TY - JOUR

T1 - Fluorinated steroids and their derivatives

AU - Jasem, Yosef Al

AU - Thiemann, Thies

AU - Gano, Lurdes

AU - Oliveira, Maria Cristina

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Fluorinated steroids have found entry into the list of important pharmaceuticals. Fluorinated corticosteroids are being used as topical drugs against rheumatism and inflammatory skin diseases or as inhalation drugs again asthma. A number of fluorinated steroids bind strongly to the estrogen or the progesterone receptor. With the availability of [18F]fluorine as a radiolabel, radiofluorinated steroids are being developed as potential positron emission tomography (PET) imaging agents. This article presents an overview of preparative methods to fluorinated steroids as well as of the uses of these compounds.

AB - Fluorinated steroids have found entry into the list of important pharmaceuticals. Fluorinated corticosteroids are being used as topical drugs against rheumatism and inflammatory skin diseases or as inhalation drugs again asthma. A number of fluorinated steroids bind strongly to the estrogen or the progesterone receptor. With the availability of [18F]fluorine as a radiolabel, radiofluorinated steroids are being developed as potential positron emission tomography (PET) imaging agents. This article presents an overview of preparative methods to fluorinated steroids as well as of the uses of these compounds.

KW - Corticosteroids

KW - Estrogen receptor ligands

KW - Fluorination

KW - Positron emission tomography (PET)

KW - Radiolabelling

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DO - 10.1016/j.jfluchem.2016.03.009

M3 - Review article

AN - SCOPUS:84962226693

SN - 0022-1139

VL - 185

SP - 48

EP - 85

JO - Journal of Fluorine Chemistry

JF - Journal of Fluorine Chemistry

ER -

Fluorinated steroids and their derivatives

Abstract

Keywords

ASJC Scopus subject areas

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