TY - JOUR
T1 - Foscarnet salvage therapy for acyclovir-resistant varicella zoster
T2 - Report of a novel thymidine kinase mutation and review of the literature
AU - Hatchette, Todd
AU - Tipples, Graham A.
AU - Peters, Geoff
AU - Alsuwaidi, Ahmed
AU - Zhou, Jianwei
AU - Mailman, Timothy Lloyd
PY - 2008/1
Y1 - 2008/1
N2 - The authors describe an acyclovir-resistant varicella zoster virus infection in a pediatric patient after hematopoietic stem cell transplant, the use of foscarnet as salvage therapy, and review the literature to clarify the pediatric experience with foscarnet in this setting. A novel thymidine kinase mutation is described, along with a new phenotypic assay for characterizing acyclovir resistance in varicella zoster virus.
AB - The authors describe an acyclovir-resistant varicella zoster virus infection in a pediatric patient after hematopoietic stem cell transplant, the use of foscarnet as salvage therapy, and review the literature to clarify the pediatric experience with foscarnet in this setting. A novel thymidine kinase mutation is described, along with a new phenotypic assay for characterizing acyclovir resistance in varicella zoster virus.
KW - Acyclovir resistance
KW - Foscarnet
KW - VZV
UR - http://www.scopus.com/inward/record.url?scp=37549062638&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=37549062638&partnerID=8YFLogxK
U2 - 10.1097/INF.0b013e3181598315
DO - 10.1097/INF.0b013e3181598315
M3 - Article
C2 - 18162946
AN - SCOPUS:37549062638
SN - 0891-3668
VL - 27
SP - 75
EP - 77
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
IS - 1
ER -