Foscarnet salvage therapy for acyclovir-resistant varicella zoster: Report of a novel thymidine kinase mutation and review of the literature

Todd Hatchette; Graham A. Tipples; Geoff Peters; Ahmed Alsuwaidi; Jianwei Zhou; Timothy Lloyd Mailman

doi:10.1097/INF.0b013e3181598315

Foscarnet salvage therapy for acyclovir-resistant varicella zoster: Report of a novel thymidine kinase mutation and review of the literature

Todd Hatchette
, Graham A. Tipples
, Geoff Peters
, Ahmed Alsuwaidi
, Jianwei Zhou
, Timothy Lloyd Mailman

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

The authors describe an acyclovir-resistant varicella zoster virus infection in a pediatric patient after hematopoietic stem cell transplant, the use of foscarnet as salvage therapy, and review the literature to clarify the pediatric experience with foscarnet in this setting. A novel thymidine kinase mutation is described, along with a new phenotypic assay for characterizing acyclovir resistance in varicella zoster virus.

Original language	English
Pages (from-to)	75-77
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	27
Issue number	1
DOIs	https://doi.org/10.1097/INF.0b013e3181598315
Publication status	Published - Jan 2008
Externally published	Yes

Keywords

Acyclovir resistance
Foscarnet
VZV

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/INF.0b013e3181598315

Cite this

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title = "Foscarnet salvage therapy for acyclovir-resistant varicella zoster: Report of a novel thymidine kinase mutation and review of the literature",

abstract = "The authors describe an acyclovir-resistant varicella zoster virus infection in a pediatric patient after hematopoietic stem cell transplant, the use of foscarnet as salvage therapy, and review the literature to clarify the pediatric experience with foscarnet in this setting. A novel thymidine kinase mutation is described, along with a new phenotypic assay for characterizing acyclovir resistance in varicella zoster virus.",

keywords = "Acyclovir resistance, Foscarnet, VZV",

author = "Todd Hatchette and Tipples, \{Graham A.\} and Geoff Peters and Ahmed Alsuwaidi and Jianwei Zhou and Mailman, \{Timothy Lloyd\}",

year = "2008",

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doi = "10.1097/INF.0b013e3181598315",

language = "English",

volume = "27",

pages = "75--77",

journal = "Pediatric Infectious Disease Journal",

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T2 - Report of a novel thymidine kinase mutation and review of the literature

AU - Hatchette, Todd

AU - Tipples, Graham A.

AU - Peters, Geoff

AU - Alsuwaidi, Ahmed

AU - Zhou, Jianwei

AU - Mailman, Timothy Lloyd

PY - 2008/1

Y1 - 2008/1

N2 - The authors describe an acyclovir-resistant varicella zoster virus infection in a pediatric patient after hematopoietic stem cell transplant, the use of foscarnet as salvage therapy, and review the literature to clarify the pediatric experience with foscarnet in this setting. A novel thymidine kinase mutation is described, along with a new phenotypic assay for characterizing acyclovir resistance in varicella zoster virus.

AB - The authors describe an acyclovir-resistant varicella zoster virus infection in a pediatric patient after hematopoietic stem cell transplant, the use of foscarnet as salvage therapy, and review the literature to clarify the pediatric experience with foscarnet in this setting. A novel thymidine kinase mutation is described, along with a new phenotypic assay for characterizing acyclovir resistance in varicella zoster virus.

KW - Acyclovir resistance

KW - Foscarnet

KW - VZV

UR - https://www.scopus.com/pages/publications/37549062638

UR - https://www.scopus.com/pages/publications/37549062638#tab=citedBy

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DO - 10.1097/INF.0b013e3181598315

M3 - Article

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VL - 27

SP - 75

EP - 77

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 1

ER -

Foscarnet salvage therapy for acyclovir-resistant varicella zoster: Report of a novel thymidine kinase mutation and review of the literature

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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