Free radical scanvenging and antioxidant effects of some anthraquinone derivatives

Abderrahmane Baghiani; Noureddine Charef; Meriem Djarmouni; Haythem A. Saadeh; Lekhmici Arrar; Mohammad S. Mubarak

doi:10.2174/157340611797928424

Free radical scanvenging and antioxidant effects of some anthraquinone derivatives

Abderrahmane Baghiani, Noureddine Charef, Meriem Djarmouni, Haythem A. Saadeh, Lekhmici Arrar, Mohammad S. Mubarak

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

In this study, the screening of five anthraquinones (purpurin, xanthopurpurin, rubiadin, kermisic acid and flavokermisic acid), for their free radical scavenging and antioxidant effects was carried out, using three complementary methods. DPPH (2,2-diphenyl-1-picrylhydrazyl) revealed that purpurin has a scavenging effect with IC50 = 3.491 ± 0.014 βg/ml. Results of β-carotene / linoleic acid assay showed that kermisic and flavokermisic acids have significant inhibition of lipid peroxidation with I % = 76.1 ± 1.5 % and 68.6 ± 2.5 %, respectively. In addition, the ferrous ion chelating test showed that only purpurin, with small concentrations, interferes in a dose dependant manner with the formation of Fe2+- ferrozine complex. These results are promising for further studies of the biological and pathological effects of these natural products.

Original language	English
Pages (from-to)	639-644
Number of pages	6
Journal	Medicinal Chemistry
Volume	7
Issue number	6
DOIs	https://doi.org/10.2174/157340611797928424
Publication status	Published - Nov 2011
Externally published	Yes

Keywords

Anthraquinones
Antioxidant
Free radical
Ion chelating
Lipid peroxidation
Scavenger

ASJC Scopus subject areas

Drug Discovery

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10.2174/157340611797928424

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title = "Free radical scanvenging and antioxidant effects of some anthraquinone derivatives",

abstract = "In this study, the screening of five anthraquinones (purpurin, xanthopurpurin, rubiadin, kermisic acid and flavokermisic acid), for their free radical scavenging and antioxidant effects was carried out, using three complementary methods. DPPH (2,2-diphenyl-1-picrylhydrazyl) revealed that purpurin has a scavenging effect with IC50 = 3.491 ± 0.014 βg/ml. Results of β-carotene / linoleic acid assay showed that kermisic and flavokermisic acids have significant inhibition of lipid peroxidation with I % = 76.1 ± 1.5 % and 68.6 ± 2.5 %, respectively. In addition, the ferrous ion chelating test showed that only purpurin, with small concentrations, interferes in a dose dependant manner with the formation of Fe2+- ferrozine complex. These results are promising for further studies of the biological and pathological effects of these natural products.",

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author = "Abderrahmane Baghiani and Noureddine Charef and Meriem Djarmouni and Saadeh, {Haythem A.} and Lekhmici Arrar and Mubarak, {Mohammad S.}",

year = "2011",

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doi = "10.2174/157340611797928424",

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AU - Baghiani, Abderrahmane

AU - Charef, Noureddine

AU - Djarmouni, Meriem

AU - Saadeh, Haythem A.

AU - Arrar, Lekhmici

AU - Mubarak, Mohammad S.

PY - 2011/11

Y1 - 2011/11

N2 - In this study, the screening of five anthraquinones (purpurin, xanthopurpurin, rubiadin, kermisic acid and flavokermisic acid), for their free radical scavenging and antioxidant effects was carried out, using three complementary methods. DPPH (2,2-diphenyl-1-picrylhydrazyl) revealed that purpurin has a scavenging effect with IC50 = 3.491 ± 0.014 βg/ml. Results of β-carotene / linoleic acid assay showed that kermisic and flavokermisic acids have significant inhibition of lipid peroxidation with I % = 76.1 ± 1.5 % and 68.6 ± 2.5 %, respectively. In addition, the ferrous ion chelating test showed that only purpurin, with small concentrations, interferes in a dose dependant manner with the formation of Fe2+- ferrozine complex. These results are promising for further studies of the biological and pathological effects of these natural products.

AB - In this study, the screening of five anthraquinones (purpurin, xanthopurpurin, rubiadin, kermisic acid and flavokermisic acid), for their free radical scavenging and antioxidant effects was carried out, using three complementary methods. DPPH (2,2-diphenyl-1-picrylhydrazyl) revealed that purpurin has a scavenging effect with IC50 = 3.491 ± 0.014 βg/ml. Results of β-carotene / linoleic acid assay showed that kermisic and flavokermisic acids have significant inhibition of lipid peroxidation with I % = 76.1 ± 1.5 % and 68.6 ± 2.5 %, respectively. In addition, the ferrous ion chelating test showed that only purpurin, with small concentrations, interferes in a dose dependant manner with the formation of Fe2+- ferrozine complex. These results are promising for further studies of the biological and pathological effects of these natural products.

KW - Anthraquinones

KW - Antioxidant

KW - Free radical

KW - Ion chelating

KW - Lipid peroxidation

KW - Scavenger

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Free radical scanvenging and antioxidant effects of some anthraquinone derivatives

Abstract

Keywords

ASJC Scopus subject areas

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