Frequency-dependent effect of ethanol on action potentials of frog skeletal muscle fibers

M. Oz, G. B. Frank

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The effects of ethanol at the concentrations of 88 mM (0.5%) and 165 mM (1%) on single and repetitively elicited sodium action potentials were investigated in frog skeletal muscle fibers. At the concentrations used, although single action potentials remained intact, repetitively generated action potentials elicited with the stimulation frequency of 100 Hz for 2 sec were greatly inhibited. The inhibition of repetitively elicited sodium action potentials was completely reversed at 25 Hz. In conclusion, the results indicate that ethanol inhibits sodium action potentials in a frequency-dependent manner.

Original languageEnglish
Pages (from-to)295-298
Number of pages4
JournalMethods and Findings in Experimental and Clinical Pharmacology
Volume17
Issue number5
Publication statusPublished - 1995
Externally publishedYes

Keywords

  • ethanol
  • sodium channels

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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