Fruit and Vegetable Intake and Hip Fracture Incidence in Older Men and Women: The CHANCES Project

Vassiliki Benetou, Philippos Orfanos, Diane Feskanich, Karl Michaëlsson, Ulrika Pettersson-Kymmer, Sture Eriksson, Francine Grodstein, Alicja Wolk, Andrea Bellavia, Luai A. Ahmed, Paolo Boffeta, Antonia Trichopoulou

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


The role of fruit and vegetable intake in relation to fracture prevention during adulthood and beyond is not adequately understood. We investigated the potential association between fruit and vegetable intake and hip fracture incidence in a large sample of older adults from Europe and the United States. A total of 142,018 individuals (116,509 women) aged ≥60 years, from five cohorts, were followed up prospectively for 1,911,482 person-years, accumulating 5552 hip fractures. Fruit and vegetable intake was assessed by validated, cohort-specific, food-frequency questionnaires (FFQ). Ηip fractures were ascertained through national patient registers or telephone interviews/questionnaires. Adjusted hazard ratios (HRs) derived by Cox proportional hazards regression were estimated for each cohort and subsequently pooled using random effects meta-analysis. Intake of ≤1 serving/day of fruit and vegetables combined was associated with 39% higher hip fracture risk (pooled adjusted HR, 1.39; 95% confidence interval [CI], 1.20 to 1.58) in comparison with moderate intake (>3 and ≤5 servings/day) (pfor heterogeneity = 0.505), whereas higher intakes (>5 servings/day) were not associated with lower risk in comparison with the same reference. Associations were more evident among women. We concluded that a daily intake of 1 or <1 servings of fruits and vegetables was associated with increased hip fracture risk in relation to moderate daily intakes. Older adults with such low fruit and vegetable consumption may benefit from raising their intakes to moderate amounts in order to reduce their hip fracture risk.

Original languageEnglish
Pages (from-to)1743-1752
Number of pages10
JournalJournal of Bone and Mineral Research
Issue number9
Publication statusPublished - Sept 1 2016



ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine


Dive into the research topics of 'Fruit and Vegetable Intake and Hip Fracture Incidence in Older Men and Women: The CHANCES Project'. Together they form a unique fingerprint.

Cite this